National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China.
Department of Metabolism and Endocrinology, Xuhui Central Hospital, Fudan University, Shanghai, China.
Horm Metab Res. 2022 Mar;54(3):162-167. doi: 10.1055/a-1756-4937. Epub 2022 Mar 11.
The aim of the study was to investigate the usefulness of metanephrine (MN) and normetanephrine (NMN) in bilateral simultaneous adrenal vein sampling (AVS) with and without ACTH stimulation. The study was conducted in a single referral center. Prospective recruited patients with PA were treated with AVS. The effects of cortisol, MN and NMN on selectivity catheterization were assessed and determined by lateralization. We enrolled 54 patients with PA who were treated with simultaneous bilateral AVS with ACTH. The Selectivity Index (SI) calculated by MN was higher than that calculated by other indicators (p<0.001), the catheterization success rate of MN at baseline was the same as that of cortisol after ACTH stimulation, and in lateralization diagnosis, MN was not inferior to cortisol. In conclusion, among the studied indicators, MN is the best index for determining the catheterization selectivity in AVS, especially in the absence of ACTH stimulation.
本研究旨在探讨去甲肾上腺素（MN）和间甲肾上腺素（NMN）在双侧同步肾上腺静脉采样（AVS）中的作用，包括有无 ACTH 刺激。该研究在一家单一的转诊中心进行。对接受 AVS 治疗的 PA 患者进行前瞻性招募。通过侧化评估和确定皮质醇、MN 和 NMN 对选择性导管插入术的影响。我们招募了 54 例接受 ACTH 双侧同步 AVS 治疗的 PA 患者。MN 计算的选择性指数（SI）高于其他指标（p<0.001），MN 在基线时的导管插入成功率与 ACTH 刺激后皮质醇相同，在侧化诊断中，MN 不逊于皮质醇。总之，在研究的指标中，MN 是确定 AVS 导管插入选择性的最佳指标，尤其是在没有 ACTH 刺激的情况下。
