19岁男性患者中对免疫疗法和CAR-T疗法耐药的极罕见近单倍体急性淋巴细胞白血病。
Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient.
作者信息
Arpas Tomas, Jelinkova Hana, Hrabovsky Stepan, Orsulova Martina, Vrzalova Zuzana, Navrkalova Veronika, Brhelova Eva, Bryjova Lenka, Bulikova Alena, Ondrouskova Eva, Sejnohova Marketa, Folber Frantisek, Sedová Petra, Mayer Jiri, Pospisilova Sarka, Jarosova Marie, Doubek Michael
机构信息
Department of Internal Medicine, Hematology and Oncology University Hospital and Faculty of Medicine Brno Czechia.
Center of Molecular Biology and Genetics Department of Internal Medicine, Hematology and Oncology University Hospital and Faculty of Medicine Brno Czechia.
出版信息
Clin Case Rep. 2022 Mar 3;10(3):e05545. doi: 10.1002/ccr3.5545. eCollection 2022 Mar.
Near-haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR-T therapy.
近单倍体急性淋巴细胞白血病是该疾病中一个罕见的亚组，因其预后极差且对包括新型单克隆抗体和嵌合抗原受体T细胞（CAR-T）疗法在内的治疗具有抗性而非常重要。
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