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多发性骨髓瘤患者中出现爱泼斯坦-巴尔病毒黏膜皮肤溃疡后发生霍奇金淋巴瘤。

Epstein-Barr virus mucocutaneous ulcer followed by Hodgkin lymphoma in multiple myeloma patient.

作者信息

Forster Moriah, Fedoriw Yuri, Tuchman Sascha, Grover Natalie

机构信息

Department of Internal Medicine University of North Carolina Chapel Hill North Carolina USA.

Department of Pathology and Lab Medicine University of North Carolina Chapel Hill North Carolina USA.

出版信息

Clin Case Rep. 2022 Mar 3;10(3):e05528. doi: 10.1002/ccr3.5528. eCollection 2022 Mar.

DOI:10.1002/ccr3.5528
PMID:35280097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8894576/
Abstract

Epstein-Barr virus mucocutaneous ulcers (EBV MCU) are B-cell lymphoproliferative disorders associated with immunosuppression. We report EBV MCU in a multiple myeloma patient on lenalidomide maintenance after stem cell transplant that resolved with decreased immunosuppression. Furthermore, the subsequent development of classical Hodgkin lymphoma suggests an underlying predisposition to EBV-driven lymphoproliferative disorders.

摘要

爱泼斯坦-巴尔病毒黏膜皮肤溃疡（EBV MCU）是与免疫抑制相关的B细胞淋巴增殖性疾病。我们报告了1例多发性骨髓瘤患者在干细胞移植后接受来那度胺维持治疗期间发生EBV MCU，随着免疫抑制的减轻而痊愈。此外，随后发生的经典型霍奇金淋巴瘤提示存在EBV驱动的淋巴增殖性疾病的潜在易感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a8e/8894576/623a929b5e98/CCR3-10-e05528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a8e/8894576/623a929b5e98/CCR3-10-e05528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a8e/8894576/623a929b5e98/CCR3-10-e05528-g002.jpg

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本文引用的文献

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J Surg Case Rep. 2020 Aug 26;2020(8):rjaa332. doi: 10.1093/jscr/rjaa332. eCollection 2020 Aug.
2
Gastric EBV-positive mucocutaneous ulcer: A rare pathological entity.胃EB病毒阳性黏膜皮肤溃疡：一种罕见的病理实体。
Clin Case Rep. 2020 Apr 13;8(7):1130-1133. doi: 10.1002/ccr3.2837. eCollection 2020 Jul.
3
A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.
罕见的 Epstein-Barr 病毒阳性黏膜皮肤溃疡发展为肠梗阻：病例报告。
BMC Gastroenterol. 2020 Jan 13;20(1):9. doi: 10.1186/s12876-020-1162-2.
4
A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects.聚焦临床和病理方面的EB病毒阳性黏膜皮肤溃疡综述。
J Clin Exp Hematop. 2019;59(2):64-71. doi: 10.3960/jslrt.18039.
5
EBV-positive mucocutaneous ulcer arising in rheumatoid arthritis patients treated with methotrexate: Single center series of nine cases.在接受甲氨蝶呤治疗的类风湿关节炎患者中出现的EB病毒阳性黏膜皮肤溃疡：单中心9例系列报道
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6
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