ALDH1A1/B1的转录表达作为甲状腺癌患者生存的独立指标
Transcriptional Expressions of ALDH1A1/B1 as Independent Indicators for the Survival of Thyroid Cancer Patients.
作者信息
Cui Ying, Liu Yao, Mu Lan, Li Yang, Wu Gang
机构信息
Department of Otorhinolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
出版信息
Front Oncol. 2022 Feb 23;12:821958. doi: 10.3389/fonc.2022.821958. eCollection 2022.
BACKGROUND
Aldehyde dehydrogenase (ALDH) 1 is an important enzyme involved in the regulation of several cellular mechanisms aldehyde detoxification. High ALDH1 levels were correlated with tumorigenesis and stemness maintenance in cancer.
METHODS
We used UALCAN, Human Protein Atlas, Kaplan-Meier plotter, TISIDB, TIMER, and KOBAS databases to investigate the expression and role of ALDH1 in thyroid cancer progression. In addition, quantitative real-time polymerase chain reaction was performed to detect the expression of the target genes in thyroid cancer cell lines and cancer tissues.
RESULTS
Expression of ALDH1A1/B1 was significantly decreased based on individual cancer stages and tumor histology, and high levels of ALDH1A1/B1 were associated with poor overall survival in thyroid cancer patients. Moreover, ALDH1A1/B1 expression was negatively correlated with immune-stimulating genes, major histocompatibility complex, chemokines, and receptors.
CONCLUSIONS
These results suggest that ALDH1A1/B1 might serve as potential prognostic biomarkers for thyroid cancer diagnosis.
背景
醛脱氢酶（ALDH）1是一种参与多种细胞机制（醛解毒）调节的重要酶。ALDH1水平升高与癌症的肿瘤发生和干性维持相关。
方法
我们使用UALCAN、人类蛋白质图谱、Kaplan-Meier绘图仪、TISIDB、TIMER和KOBAS数据库来研究ALDH1在甲状腺癌进展中的表达和作用。此外，进行定量实时聚合酶链反应以检测甲状腺癌细胞系和癌组织中靶基因的表达。
结果
基于个体癌症阶段和肿瘤组织学，ALDH1A1/B1的表达显著降低，并且ALDH1A1/B1水平高与甲状腺癌患者的总体生存不良相关。此外，ALDH1A1/B1表达与免疫刺激基因、主要组织相容性复合体、趋化因子和受体呈负相关。
结论
这些结果表明，ALDH1A1/B1可能作为甲状腺癌诊断的潜在预后生物标志物。
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