Mosevitskiĭ M I
Genetika. 1978;14(7):1127-45.
Three basic versions for the formation of circularly permuted and terminally redundant chromosomes with rings, concatemers, or fragments as replicative intermediates were considered. Experimental results show that the chromosome of T-even phage can turn into 4-6 large fragments soon after it penetrates inside the Escherichia coli cell. The fragments are capable for autonomous replication and contribute their material to progeny phage chromosomes. These results confirm the suggestion that circularly permuted and terminally redundant chromosomes of T-even phages are made of fragments. A theoretical analysis of different modes of parental chromosome fragments formation, autonomous replication and ordered association was carried out. In particular, it was emphasized that at a low multiplicity of infection the reassociation of fragments by means of recombination can be accomplished only if breaks in complementary strands of the parental chromosome were made with a shift for about 3000 nucleotides. Complexity is a feature of linear chromosomes that ensures their reproduction without defects at the ends.
考虑了三种以环状、多联体或片段作为复制中间体形成环状排列和末端冗余染色体的基本模式。实验结果表明，T偶数噬菌体的染色体在侵入大肠杆菌细胞后不久就会变成4 - 6个大片段。这些片段能够自主复制，并为子代噬菌体染色体提供物质。这些结果证实了T偶数噬菌体的环状排列和末端冗余染色体由片段组成的观点。对亲代染色体片段形成、自主复制和有序关联的不同模式进行了理论分析。特别强调的是，在低感染复数时，只有当亲代染色体互补链中的断裂发生约3000个核苷酸的移位时，片段才能通过重组重新结合。复杂性是线性染色体的一个特征，可确保其末端无缺陷地复制。
