Eberhart R J
J Dairy Sci. 1986 Jun;69(6):1721-32. doi: 10.3168/jds.S0022-0302(86)80591-4.
The objective of mastitis control during the dry period is to have as few infected quarters as possible at calving. This depends on enhancing elimination of infections present at drying off and on reducing the new infection rate during the dry period; prevention of new infection appears to offer greater long-term benefits. Incidence of new infection is high in the dry period with periods of high susceptibility shortly after dry off and again prepartum. Pathogens of both contagious and environmental origin cause new dry period infections; however, exposure to contagious pathogens probably decreases with cessation of regular milking, whereas exposure to environmental pathogens continues throughout the dry period. Varying susceptibility over the dry period may be affected by bacterial loads on the teat skin, characteristics of the teat canal, and internal protective mechanisms. At present, antibiotic therapy at the end of lactation is the most effective means of eliminating existing infections and preventing new infections. Although there are reasons to prefer selective therapy, present evidence favors a recommendation for treatment of all cows at the time of drying off. A shortcoming of present therapy regimens for the dry period is that they provide little or no protective effect against new infection prepartum. Other mastitis control methods and management practices have not been shown conclusively to reduce new dry period infections. However, it appears that reduction of exposure to environmental pathogens during dry period should be recommended. More effective means to reduce new infections in the prepartum period are needed.
干奶期乳腺炎防控的目标是在产犊时尽量减少感染的乳腺区数量。这取决于加强对干奶时已存在感染的清除以及降低干奶期新感染率;预防新感染似乎能带来更大的长期益处。干奶期新感染发生率很高,在干奶后不久以及产前又会出现高易感期。传染性和环境源性病原体都会引发干奶期新感染;然而,随着常规挤奶的停止,接触传染性病原体的情况可能会减少,而在整个干奶期都持续存在接触环境病原体的情况。干奶期不同阶段的易感性差异可能受乳头皮肤细菌载量、乳头管特征以及内部保护机制的影响。目前,泌乳期末的抗生素治疗是清除现有感染和预防新感染的最有效手段。尽管有理由倾向于选择性治疗,但现有证据支持在干奶时对所有奶牛进行治疗的建议。目前干奶期治疗方案的一个缺点是它们对产前新感染几乎没有或根本没有保护作用。尚未确凿证明其他乳腺炎防控方法和管理措施能减少干奶期新感染。然而,似乎应该建议在干奶期减少与环境病原体的接触。需要更有效的方法来减少产前新感染。