North End Medical Centre, London, United Kingdom; UCL Medical School, London, United Kingdom.
Imperial College School of Medicine, London, United Kingdom.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102800. doi: 10.1016/j.pdpdt.2022.102800. Epub 2022 Mar 11.
Healthcare related quality of life (QoL) is defined as the impact one's level of health and wellbeing has on a number of domains, including physical, mental, spiritual and social functions. Photodynamic therapy (PDT), a cancer treatment modality, is increasingly used to treat or palliate head and neck pathologies. Due to the complex nature of this area of the body, both the pathology and the treatment of it can severely affect the quality of life. Thus far, no questionnaire has been developed which focuses on quality-of-life post-PDT of head and neck pathologies.
We have developed the University College London Quality of Life Questionnaire for Patients undergoing PDT in the Head and Neck, using meta-tetra(hydroxyphenyl)chlorin (mTHPC) as the photosensitiser. This was modified from the University of Washington quality of life (UW-QOL) questionnaire. Thirty-eight patients who received mTHPC-PDT for various head and neck pathologies completed the questionnaire, with a mean follow-up of 56 days.
All patients reported improved QoL following mTHPC-PDT. The main problem that was reported was post-PDT pain, which is a common side effect. Visual symptoms, breathing, speaking and swallowing problems improved significantly in the 4th week following treatment and significant improvement in activities of daily living, social life, mood and anxiety were reported in the subsequent weeks.
mTHPC-PDT confers improvement in QoL score in selected head and neck cancer patients with figures comparable to other treatment modalities. This exploratory study demonstrated patterns of QoL outcome. Further work needs to be done for survey validation and inclusion of a larger cohort which will allow optimal sub-group analysis and help guide further interventions.
医疗相关生活质量（QoL）被定义为一个人的健康和福祉水平对许多领域的影响，包括身体、心理、精神和社会功能。光动力疗法（PDT）是一种癌症治疗方法，越来越多地用于治疗或缓解头颈部病变。由于该身体区域的复杂性，病变及其治疗都会严重影响生活质量。迄今为止，尚未开发出专门针对头颈部病变 PDT 后生活质量的问卷。
我们使用meta-四（羟苯基）氯（mTHPC）作为光敏剂，开发了用于头颈部 PDT 的伦敦大学学院患者生活质量问卷。这是从华盛顿大学生活质量（UW-QOL）问卷修改而来的。38 名接受 mTHPC-PDT 治疗各种头颈部病变的患者完成了问卷，平均随访时间为 56 天。
所有患者在接受 mTHPC-PDT 后报告生活质量得到改善。报告的主要问题是 PDT 后疼痛，这是一种常见的副作用。治疗后第 4 周，视觉症状、呼吸、说话和吞咽问题显著改善，随后几周报告日常生活活动、社会生活、情绪和焦虑显著改善。
mTHPC-PDT 可改善选定头颈部癌症患者的生活质量评分，与其他治疗方法相当。这项探索性研究显示了生活质量结果的模式。需要进一步开展调查验证工作，并纳入更大的队列，以允许进行最佳亚组分析，并有助于指导进一步的干预措施。
