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大剂量胰岛素皮下注射后的胰岛素分布。

Biodistribution of Insulin Following Massive Insulin Subcutaneous Injection.

机构信息

Department of Legal Medicine, Osaka City University Medical School, Japan.

Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Japan.

出版信息

Intern Med. 2022 Jul 1;61(13):1999-2006. doi: 10.2169/internalmedicine.7364-21. Epub 2022 Mar 12.

DOI:10.2169/internalmedicine.7364-21
PMID:35283372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9334236/
Abstract

A man in his 30s injected insulin several times into his abdomen and was found dead several hours later. Micropathological findings showed alveolar injury with hemorrhaging and cerebral parietal lobe nerve cell edema. Biochemical examinations showed that the blood insulin level was high, significantly so at the insulin injection sites. The blood glucose and C-peptide levels were low. The insulin level in the kidneys was low. In forensic medicine, a postmortem diagnosis of insulin subcutaneous injection is often difficult. When insulin injection is suspected, particularly high insulin levels can be expected at the insulin injection site, rather than in the blood.

摘要

一名 30 多岁的男子多次将胰岛素注入腹部,数小时后被发现死亡。显微镜下病理检查显示肺泡损伤伴出血和大脑顶叶神经细胞水肿。生化检查显示血液胰岛素水平升高,在胰岛素注射部位尤为明显。血糖和 C 肽水平低。肾脏中的胰岛素水平低。在法医学中,胰岛素皮下注射的死后诊断通常很困难。当怀疑胰岛素注射时,特别是在胰岛素注射部位,而不是在血液中,可以预期胰岛素水平会很高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/0514a1f24046/1349-7235-61-1999-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/4a6407754fd8/1349-7235-61-1999-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/216e50a3fac0/1349-7235-61-1999-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/0514a1f24046/1349-7235-61-1999-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/4a6407754fd8/1349-7235-61-1999-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/216e50a3fac0/1349-7235-61-1999-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/9334236/0514a1f24046/1349-7235-61-1999-g003.jpg

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World Neurosurg. 2020 Apr;136:e514-e534. doi: 10.1016/j.wneu.2020.01.056. Epub 2020 Jan 16.
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Severe hypoglycemia and hyponatremia caused by hypopituitarism in a female patient with type 1 diabetes: A case report.一名 1 型糖尿病女性患者因垂体功能减退导致严重低血糖和低钠血症:病例报告
Medicine (Baltimore). 2019 Jul;98(28):e16407. doi: 10.1097/MD.0000000000016407.
3
The Determination of Insulin Overdose in Postmortem Investigations.
死后调查中胰岛素过量的测定
Acad Forensic Pathol. 2016 Jun;6(2):174-183. doi: 10.23907/2016.019. Epub 2016 Jun 1.
4
Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism.m.3243A>G 突变的定量变异导致能量代谢的离散变化。
Sci Rep. 2019 Apr 8;9(1):5752. doi: 10.1038/s41598-019-42262-2.
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Validation of a Fully Automated Immunoaffinity Workflow for the Detection and Quantification of Insulin Analogs by LC-MS-MS in Postmortem Vitreous Humor.验证 LC-MS-MS 法检测死后玻璃体液中胰岛素类似物的完全自动化免疫亲和工作流程的有效性。
J Anal Toxicol. 2019 Aug 23;43(7):505-511. doi: 10.1093/jat/bkz014.
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