Rahiman Emine A, Patra Pratap Kumar, Suri Deepti, Rawat Amit, Singh Surjit
Department of Pediatrics, Pediatric Allergy- Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Indian J Nephrol. 2022 Jan-Feb;32(1):22-27. doi: 10.4103/ijn.IJN_124_20. Epub 2021 Sep 21.
Renal dysfunction and progression to end stage renal disease is well known in human immunodeficiency virus (HIV) infection. We studied the role of microalbuminuria and urinary NGAL levels in children with HIV infection for the prediction of renal dysfunction.
A cross-sectional study was carried out and 60 HIV infected children, aged (18 months to 15 years) were screened for microalbuminuria by nephelometry and for uNGAL by ELISA. Thirty healthy children were screened for uNGAL for normative data in Indian children.
The prevalence of microalbuminuria in studied population was 3.3%. The mean uNGAL and uNGAL/creatinine in study population was higher than controls (26.94 ± 93.12 ng/ml vs. 88.94 ± 345.20 mcg/g, and 15.53 ± 37.52 ng/ml vs. 30.12 ± 78.66 ng/ml; = 0.003, = 0.002). Children with lower CD4 counts had significant higher mean Albumin Creatinine Ratio (ACR) and mean uNGAL; = 0.03, = 0.01.
uNGAL and urine microalbumin are useful biomarkers of early tubular and glomerular injury in children with HIV infection.
肾功能不全及进展至终末期肾病在人类免疫缺陷病毒（HIV）感染中是众所周知的。我们研究了微量白蛋白尿和尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平在HIV感染儿童中对肾功能不全的预测作用。
开展了一项横断面研究，对60名年龄在18个月至15岁的HIV感染儿童进行了散射比浊法检测微量白蛋白尿以及酶联免疫吸附测定法检测尿NGAL。对30名健康儿童检测尿NGAL以获取印度儿童的正常数据。
研究人群中微量白蛋白尿的患病率为3.3%。研究人群的平均尿NGAL和尿NGAL/肌酐高于对照组（26.94±93.12纳克/毫升对88.94±345.20微克/克，以及15.53±37.52纳克/毫升对30.12±78.66纳克/毫升；P = 0.003，P = 0.002）。CD4细胞计数较低的儿童平均白蛋白肌酐比值（ACR）和平均尿NGAL显著更高；P = 0.03，P = 0.01。
尿NGAL和尿微量白蛋白是HIV感染儿童早期肾小管和肾小球损伤的有用生物标志物。
