Sharma Gorav, Mathai Sheila S
Department of Pediatrics, Armed Forces Medical College, Wanowrie PO, Pune, Maharashtra, 411040, India.
Indian J Pediatr. 2017 Jun;84(6):417-419. doi: 10.1007/s12098-017-2294-4. Epub 2017 Feb 8.
To study the prevalence of covert or early renal involvement among human immunodeficiency virus (HIV) positive children.
A cross-sectional observational study was carried out on 250 HIV positive children (2-18 y) on follow-up in a tertiary care hospital from January 2014 through June 2015. Those who met the study criteria were evaluated for microalbuminuria and glomerular and tubular dysfunctions.
Fifty-one out of two hundred fifty (20%) children were found to have microalbuminuria though none had any other evidence of renal dysfunction. The incidence of microalbuminuria in children on Anti Retroviral Therapy (ART) and those not on ART was 20% and 21% respectively. Neither was there any difference in those with a CD4 count ≤500/cu mm compared with those with counts >500/cu mm. However, the overall CD4 counts were significantly lower in children with microalbuminuria.
Microalbuminuria was detected in 20% of asymptomatic HIV positive children suggesting early glomerular dysfunction and need for regular screening and follow-up.
研究人类免疫缺陷病毒（HIV）阳性儿童隐匿性或早期肾脏受累的患病率。
2014年1月至2015年6月，在一家三级护理医院对250名接受随访的2至18岁HIV阳性儿童进行了横断面观察性研究。符合研究标准的儿童接受了微量白蛋白尿以及肾小球和肾小管功能障碍的评估。
250名儿童中有51名（20%）被发现有微量白蛋白尿，不过没有人有任何其他肾功能障碍的证据。接受抗逆转录病毒治疗（ART）的儿童和未接受ART的儿童中微量白蛋白尿的发生率分别为20%和21%。CD4细胞计数≤500/立方毫米的儿童与计数>500/立方毫米的儿童之间也没有差异。然而，有微量白蛋白尿的儿童的总体CD4细胞计数显著更低。
在20%无症状的HIV阳性儿童中检测到微量白蛋白尿，提示早期肾小球功能障碍，需要定期筛查和随访。
