巴氯芬在慢性肾脏病中引起的神经毒性：是否存在安全剂量？
Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
作者信息
Varma Prem P, Bajpai Geet
机构信息
Department of Nephrology, Venkateshwar Hospital, Dwarka, New Delhi, India.
出版信息
Indian J Nephrol. 2022 Jan-Feb;32(1):87-89. doi: 10.4103/ijn.IJN_330_20. Epub 2022 Jan 5.
Abstract
Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6-8 h after ingestion of a single tablet and third on 4 day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment.
摘要
大多数巴氯芬中毒病例报告于肾功能受损的患者，在摄入药物后的数天至数周内。我们报告了3例慢性肾病患者中巴氯芬诱发的脑病；2例在单次服用一片药物后的6 - 8小时内出现脑病，第3例在每日两次服用2.5毫克剂量的第4天出现脑病。所有3例患者在接受血液透析治疗后均完全康复。
相似文献
1
Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?巴氯芬在慢性肾脏病中引起的神经毒性：是否存在安全剂量？
Indian J Nephrol. 2022 Jan-Feb;32(1):87-89. doi: 10.4103/ijn.IJN_330_20. Epub 2022 Jan 5.
2
Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.单剂量巴氯芬致终末期肾病患者神经毒性：病例报告。
BMC Nephrol. 2018 Dec 11;19(1):352. doi: 10.1186/s12882-018-1167-z.
3
Baclofen-induced myoclonus in patients with renal impairment: A case series.肾功能损害患者中巴氯芬诱发的肌阵挛：病例系列
SAGE Open Med Case Rep. 2023 Sep 14;11:2050313X231200966. doi: 10.1177/2050313X231200966. eCollection 2023.
4
Baclofen-induced neurotoxicity in a dialysis patient managed with continuous venovenous hemodialysis: A case report and literature review.巴氯芬在接受持续静脉-静脉血液透析治疗的透析患者中引起的神经毒性：一例报告及文献综述
Turk J Emerg Med. 2024 Jul 1;24(3):176-179. doi: 10.4103/tjem.tjem_231_23. eCollection 2024 Jul-Sep.
5
Two cases of baclofen-induced encephalopathy in hemodialysis and peritoneal dialysis patients.两例血液透析和腹膜透析患者中出现的巴氯芬脑病。
Ren Fail. 2013 Jul;35(6):860-2. doi: 10.3109/0886022X.2013.794679. Epub 2013 May 17.
6
Prevalence and risk factors of baclofen neurotoxicity in patients with severely impaired renal function.巴氯芬神经毒性在严重肾功能损害患者中的流行情况及危险因素。
Nefrologia (Engl Ed). 2020 Sep-Oct;40(5):543-551. doi: 10.1016/j.nefro.2020.03.004. Epub 2020 Jul 24.
7
Baclofen toxicity in patients with advanced nephropathy: proposal for new labeling.巴氯芬在晚期肾病患者中的毒性：新标签建议。
Am J Nephrol. 2011;34(6):491-5. doi: 10.1159/000333247. Epub 2011 Oct 26.
8
Baclofen neurotoxicity in uremic patients: is continuous ambulatory peritoneal dialysis less effective than intermittent hemodialysis?尿毒症患者的巴氯芬神经毒性：持续性非卧床腹膜透析是否比间歇性血液透析效果差？
Ren Fail. 2003 Mar;25(2):297-305. doi: 10.1081/jdi-120018730.
9
Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease.一名依赖血液透析的终末期肾病患者的巴氯芬中毒
J Emerg Med. 2017 Apr;52(4):e99-e100. doi: 10.1016/j.jemermed.2016.09.025. Epub 2016 Oct 24.
10
Baclofen has a risk of encephalopathy in older adults receiving dialysis.对于接受透析的老年人，巴氯芬有致脑病的风险。
Kidney Int. 2020 Oct;98(4):979-988. doi: 10.1016/j.kint.2020.04.047. Epub 2020 May 22.
引用本文的文献
1
Case Report: Synergistic central nervous system depression of baclofen and pregabalin: clinical pharmacist-driven case analysis and case review.病例报告：巴氯芬与普瑞巴林协同导致中枢神经系统抑制：临床药师主导的病例分析与病例回顾
Front Pharmacol. 2025 Jun 5;16:1598971. doi: 10.3389/fphar.2025.1598971. eCollection 2025.
2
Life-threatening baclofen toxicity in ESRD: a case report.终末期肾病中危及生命的巴氯芬中毒：一例报告
CEN Case Rep. 2025 Jun 13. doi: 10.1007/s13730-025-01005-1.
3
Neurological adverse events associated with baclofen: A disproportionality analysis based on FDA Adverse Event Reporting System.与巴氯芬相关的神经系统不良事件：基于美国食品药品监督管理局不良事件报告系统的不成比例性分析。
SAGE Open Med. 2025 Apr 28;13:20503121251331812. doi: 10.1177/20503121251331812. eCollection 2025.
4
Baclofen-induced neurotoxicity in a dialysis patient managed with continuous venovenous hemodialysis: A case report and literature review.巴氯芬在接受持续静脉-静脉血液透析治疗的透析患者中引起的神经毒性：一例报告及文献综述
Turk J Emerg Med. 2024 Jul 1;24(3):176-179. doi: 10.4103/tjem.tjem_231_23. eCollection 2024 Jul-Sep.
5
An Uncommon Side Effect of Baclofen Withdrawal in End Stage Renal Disease.巴氯芬戒断在终末期肾病中的一种罕见副作用。
Cureus. 2024 May 16;16(5):e60411. doi: 10.7759/cureus.60411. eCollection 2024 May.
6
Baclofen Toxicity in a Dialysis-Dependent Patient: A Case Report.一名依赖透析患者的巴氯芬中毒：病例报告
Cureus. 2023 Sep 8;15(9):e44932. doi: 10.7759/cureus.44932. eCollection 2023 Sep.
7
Baclofen-induced myoclonus in patients with renal impairment: A case series.肾功能损害患者中巴氯芬诱发的肌阵挛：病例系列
SAGE Open Med Case Rep. 2023 Sep 14;11:2050313X231200966. doi: 10.1177/2050313X231200966. eCollection 2023.
本文引用的文献
1
Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.单剂量巴氯芬致终末期肾病患者神经毒性：病例报告。
BMC Nephrol. 2018 Dec 11;19(1):352. doi: 10.1186/s12882-018-1167-z.
2
Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.终末期肾病中的医源性巴氯芬神经毒性：识别与管理
Semin Dial. 2015 Sep-Oct;28(5):525-9. doi: 10.1111/sdi.12400. Epub 2015 Jun 21.
3
Pharmacokinetic characterization of baclofen in patients with chronic kidney disease: dose adjustment recommendations.巴氯芬在慢性肾脏病患者中的药代动力学特征：剂量调整建议
J Clin Pharmacol. 2014 May;54(5):584-92. doi: 10.1002/jcph.247. Epub 2014 Jan 10.
4
Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.巴氯芬中毒：一种导致深度昏迷和非惊厥性癫痫持续状态的“娱乐性药物”——病例报告及文献复习。
Eur J Pediatr. 2012 Oct;171(10):1541-7. doi: 10.1007/s00431-012-1780-y. Epub 2012 Jun 23.
5
Role of hemodialysis in baclofen overdose with normal renal function.血液透析在肾功能正常的情况下对巴氯芬过量的作用。
Indian J Pharmacol. 2011 Nov;43(6):722-3. doi: 10.4103/0253-7613.89835.
6
Baclofen toxicity in patients with advanced nephropathy: proposal for new labeling.巴氯芬在晚期肾病患者中的毒性：新标签建议。
Am J Nephrol. 2011;34(6):491-5. doi: 10.1159/000333247. Epub 2011 Oct 26.
7
Haemodialysis clearance of baclofen.巴氯芬的血液透析清除率
Eur J Clin Pharmacol. 2007 Dec;63(12):1143-6. doi: 10.1007/s00228-007-0371-8. Epub 2007 Sep 2.
8
Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study.血液透析治疗巴氯芬过量：一项药代动力学研究。
Nephrol Dial Transplant. 2005 Feb;20(2):441-3. doi: 10.1093/ndt/gfh297. Epub 2004 Dec 22.
9
Baclofen neurotoxicity in uremic patients: is continuous ambulatory peritoneal dialysis less effective than intermittent hemodialysis?尿毒症患者的巴氯芬神经毒性：持续性非卧床腹膜透析是否比间歇性血液透析效果差？
Ren Fail. 2003 Mar;25(2):297-305. doi: 10.1081/jdi-120018730.
10
Treatment of intractable hiccup in haemodialysis patients with baclofen.用巴氯芬治疗血液透析患者的顽固性呃逆。
Am J Nephrol. 2001 Sep-Oct;21(5):427-8. doi: 10.1159/000046290.
Zotero 插件