Gupta Devika, Mendonca Satish, Chatterjee Tathagata, Trehan Arti, Singh Lavan, Tewari Rohit, Joshi Arun, Dua Arun
Department of Laboratory Science and Molecular Medicine, Army Hospital (Research and Referral), New Delhi, India.
Department of Nephrology, Army Hospital (Research and Referral), New Delhi, India.
Indian J Nephrol. 2022 Jan-Feb;32(1):67-70. doi: 10.4103/ijn.IJN_23_20. Epub 2021 Dec 30.
Plasmablastic lymphoma is a rapidly progressive CD20 negative large cell non-Hodgkin lymphoma with poor outcome. It occurs mostly in immunocompromised individuals and has a predilection for extranodal sites. They need to be differentiated from other entities sharing similar morphological features like poorly differentiated carcinoma, Burkitt's lymphoma, Alk positive large B cell lymphoma, Diffuse large B cell lymphoma, and anaplastic myeloma. EBV negativity in recipients, type, intensity, and duration of immunosuppressives used are certain risk factors in development of posttransplant lymphoproliferative disorders. High index of suspicion can help clinch the diagnosis early and prevent catastrophic consequences. Our renal transplant recipient presented with complaints of pain abdomen and malena for which he underwent exploratory laparotomy. Diagnosis was established on histopathology and timely treatment initiated reverted the disease.
浆母细胞性淋巴瘤是一种进展迅速的CD20阴性大细胞非霍奇金淋巴瘤，预后较差。它主要发生在免疫功能低下的个体中，且好发于结外部位。需要将其与其他具有相似形态特征的实体进行鉴别，如低分化癌、伯基特淋巴瘤、ALK阳性大B细胞淋巴瘤、弥漫性大B细胞淋巴瘤和间变性骨髓瘤。受者的EBV阴性、所用免疫抑制剂的类型、强度和持续时间是移植后淋巴增殖性疾病发生的某些危险因素。高度怀疑有助于早期确诊并防止灾难性后果。我们的肾移植受者因腹痛和黑便就诊，为此接受了剖腹探查术。通过组织病理学确诊，并及时开始治疗，使病情得到缓解。
