Ishak Muhammad Nu'aim, Md Shukri Norasnieda, Ramli Ramiza Ramza
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Faculty of Medicine, Universiti Sultan Zainal Abidin, Medical Campus, Terengganu, Malaysia.
Malays J Med Sci. 2022 Feb;29(1):34-42. doi: 10.21315/mjms2022.29.1.4. Epub 2022 Feb 23.
Allergic rhinitis (AR) is a long-standing disease and has been shown to cause significant impairment in patients' quality of life. Saline nasal irrigation is a proven adjunct in the treatment of AR. The addition of steroid to the saline solution can provide local steroid effect and increase the effectiveness of this technique. Our study aimed to determine the effectiveness of budesonide nasal irrigation as an adjunct to the treatment of AR, compared with saline nasal irrigation.
This was a randomised controlled study involving 99 patients diagnosed with AR, half of whom were treated with saline nasal irrigation and the other half with budesonide nasal irrigation. Parameters measured include the Sino-Nasal Outcome Test (SNOT-22) questionnaire, endoscopic nasal examination findings and blood eosinophil count.
Patients treated with budesonide nasal irrigation had significant improvement in total SNOT-22 score ( < 0.001) and improvement in the endoscopic nasal examination findings, such as nasal mucosa oedema and secretions ( < 0.001). However, there was no significant improvement of blood eosinophil count in patients treated with either budesonide or saline nasal irrigation.
Budesonide nasal irrigation is effective as an adjunct in the treatment of AR.
变应性鼻炎（AR）是一种慢性病，已被证明会严重损害患者的生活质量。鼻腔盐水冲洗是治疗AR的一种经证实的辅助方法。在盐溶液中添加类固醇可提供局部类固醇效应并提高该技术的有效性。我们的研究旨在确定与鼻腔盐水冲洗相比，布地奈德鼻腔冲洗作为AR治疗辅助手段的有效性。
这是一项随机对照研究，涉及99例被诊断为AR的患者，其中一半接受鼻腔盐水冲洗治疗，另一半接受布地奈德鼻腔冲洗治疗。测量的参数包括鼻-鼻窦结局测试（SNOT-22）问卷、鼻内镜检查结果和血液嗜酸性粒细胞计数。
接受布地奈德鼻腔冲洗治疗的患者SNOT-22总分有显著改善（<0.001），鼻内镜检查结果如鼻黏膜水肿和分泌物也有改善（<0.00'1）。然而，接受布地奈德或鼻腔盐水冲洗治疗的患者血液嗜酸性粒细胞计数均无显著改善。
布地奈德鼻腔冲洗作为AR治疗的辅助手段是有效的。
