Department of Infectious Diseases and Clinical Microbiology, University of Health Science, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey.
Department of Obstetrics and Gynecology, University of Health Science, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey.
Afr Health Sci. 2021 Dec;21(4):1567-1573. doi: 10.4314/ahs.v21i4.10.
In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more severe due to existing physiological changes. Similarly, changes during and after birth can make the patient more subceptible.
To investigate possible laboratory findings that was related to postpartum progression of COVID-19 disease.
Pregnant women who are pregnant at 28 weeks or more and who are COVID-19 positive at the time of delivery were investigated in this study. Progressed post- delivery and non-progressed COVID-19 positive pregnants' laboratory findings were analyzed. Hematological and immunological parameters associated with postpartum progressed COVID-19 disease were evaluated.
Totally 151 individuals were conducted to the study. In the prenatal analysis, higher BMI and lower albumin levels were detected in the progressed group (p<0.05). In the postpartum analysis; White Blood Cell, lymphocyte and albumin were increased, while neutrophil, NLR, LDH, CK, D-DIMER, Ferritin, CRP and IL-6 were decreased in the non-progressed group as opposite of the progressed group (p<005).
We observed that prenatal low albumin and high BMI may be related to progression of the COVID-19 disease after delivery. In progressed group, inflammatory markers were increased after delivery while in non-progressed group they were improved. These markers may be warning for the postpartum progression of COVID-19 disease.
由于存在生理变化，COVID-19 感染疾病在妊娠期间可能更为严重。同样，分娩期间和之后的变化也会使患者更容易受到影响。
研究可能与 COVID-19 疾病产后进展相关的实验室发现。
本研究调查了分娩时 COVID-19 阳性且妊娠 28 周或以上的孕妇。分析了产后进展和未进展 COVID-19 阳性孕妇的实验室检查结果。评估了与产后进展 COVID-19 疾病相关的血液学和免疫学参数。
总共对 151 人进行了研究。在产前分析中，进展组的 BMI 较高且白蛋白水平较低（p<0.05）。在产后分析中，未进展组的白细胞、淋巴细胞和白蛋白增加，而中性粒细胞、NLR、LDH、CK、D-DIMER、铁蛋白、CRP 和 IL-6 下降，与进展组相反（p<0.05）。
我们观察到产前低白蛋白和高 BMI 可能与产后 COVID-19 疾病的进展有关。在进展组中，炎症标志物在产后增加，而在未进展组中则改善。这些标志物可能是 COVID-19 疾病产后进展的预警。
