Faculty of Medicine and Pharmacy, Casablanca, Morocco, Hassan II University of Casablanca, Morocco.
Bacteriology-Virology and Hospital Hygiene Laboratory, Ibn Rochd University Hospital Centre, Casablanca, Morocco.
Afr Health Sci. 2021 Dec;21(4):1711-1714. doi: 10.4314/ahs.v21i4.26.
() is the first leading cause of invasive diseases such as meningitis, bacteremia and pneumoniae in children. In this case we report an early neonatal respiratory distress revealing meningitis caused by Serotype 17F through vertical transmission, in the newborn of 3 hours of live.
A male late preterm newborn was born by vaginal delivery at a gestational age of 34 weeks. At 3 hours of life, he was admitted for early moderate neonatal respiratory distress in the Neonatal Medicine and Resuscitation Service. Cerebrospinal fluid culture yielded belonging to serotype 17F while the blood culture was negative. The same pneumococcal serotype was recovered from the high vaginal swab of the mother. Both isolates were found susceptible to all tested antibiotics except tetracycline and chloramphenicol to which the strain was resistant. Antibiotherapy management of the child included ceftriaxone at 150mg/kg/day for 21 days, in combination with gentamycin at 5 mg/kg/day for 5 days. ciprofloxacin was added at 40mg/kg/day in two doses for a period of three weeks as the baby presented a hydrocephalus.
This finding shows that clinical manifestations of neonatal pneumococcal meningitis may be atypical and/or misleading.
（）是导致儿童脑膜炎、菌血症和肺炎等侵袭性疾病的首要原因。在本病例中，我们报告了一例通过垂直传播由 17F 血清型引起的早发性新生儿呼吸窘迫，患儿为生后 3 小时的早产儿。
一名男性晚期早产儿经阴道分娩，胎龄 34 周。生后 3 小时因早发性中度新生儿呼吸窘迫收入新生儿科进行治疗。脑脊液培养出属于血清型 17F 的 ，而血培养为阴性。母亲的阴道拭子中也分离出了相同的肺炎球菌血清型。两种分离株均对所有测试的抗生素敏感，除了对四环素和氯霉素耐药。患儿的抗生素治疗方案包括头孢曲松 150mg/kg/天，共 21 天，联合庆大霉素 5mg/kg/天，共 5 天。由于患儿出现脑积水，加用环丙沙星 40mg/kg/天，分两次给药，共 3 周。
该发现表明新生儿肺炎球菌性脑膜炎的临床表现可能不典型且/或具有误导性。
