Wilkins Simon, Yap Raymond, Mendis Shehara, Carne Peter, McMurrick Paul J
Cabrini Monash University Department of Surgery, Cabrini Hospital, Malvern, VIC, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Front Surg. 2022 Feb 24;9:818097. doi: 10.3389/fsurg.2022.818097. eCollection 2022.
Abdominoperineal resection (APR) of rectal cancer is associated with poorer oncological outcomes than anterior resection. This may be due to higher rates of intra-operative perforation (IOP) and circumferential resection margin (CRM) involvement causing higher recurrence rates and surgical complications. To address these concerns, several centers advocated a change in technique from a standard APR to a more radical extra-levator abdominoperineal excision (ELAPE). Initial reports showed that ELAPE reduced IOP rates and CRM involvement but increased wound complications and longer surgical duration. However, many of these studies had unacceptable rates of IOP and CRM before retraining in ELAPE. This may indicate that it was a sub-optimal surgical technique, which improved upon training, that had influenced the high CRM and IOP rates rather than the technique itself. Subsequent studies demonstrated that the CRM involvement rate for ELAPE was not always lower than for standard APR and, in some cases, significantly higher. The morbidity of ELAPE can be high, with studies reporting higher adverse events than APR, especially in terms of wound complications from the larger perineal incision required in ELAPE. Whether ELAPE improves short- or long-term oncological outcomes for patients has not been clearly demonstrated. The authors propose that all centers performing rectal cancer surgery audit surgical outcomes of patients undergoing APR or ELAPE and examine CRM involvement, IOP rates, and local recurrence rates, preferably through a national body. If rates of adverse technical or oncological outcomes exceed acceptable levels, then retraining in the appropriate surgical techniques may be indicated.
直肠癌的腹会阴联合切除术(APR)与前切除术相比,肿瘤学结局较差。这可能是由于术中穿孔(IOP)率和环周切缘(CRM)受累率较高,导致复发率和手术并发症增加。为了解决这些问题,一些中心主张将技术从标准的APR改为更激进的超提肌腹会阴切除术(ELAPE)。初步报告显示,ELAPE降低了IOP率和CRM受累率,但增加了伤口并发症和手术时间。然而,这些研究中的许多在接受ELAPE再培训之前,IOP和CRM发生率都不可接受。这可能表明它是一种次优的手术技术,在培训后得到了改进,影响高CRM和IOP率的是培训而非技术本身。随后的研究表明,ELAPE的CRM受累率并不总是低于标准APR,在某些情况下,甚至显著更高。ELAPE的发病率可能很高,研究报告其不良事件比APR更多,尤其是在ELAPE所需更大的会阴切口导致的伤口并发症方面。ELAPE是否能改善患者的短期或长期肿瘤学结局尚未得到明确证实。作者建议,所有进行直肠癌手术的中心都应对接受APR或ELAPE的患者的手术结局进行审核,并检查CRM受累情况、IOP率和局部复发率,最好通过国家机构进行。如果不良技术或肿瘤学结局的发生率超过可接受水平,那么可能需要进行适当手术技术的再培训。