National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of the Russian Federation, Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Scand J Immunol. 2022 Jun;95(6):e13157. doi: 10.1111/sji.13157. Epub 2022 Mar 16.
A possible mechanism of the immune tolerance in pregnancy is production of blocking antibodies which reside in placenta and protect foetal allogeneic cells from the mother's immune system. Their epitope specificity, as well as the nature of the biomolecules masked by them, is unknown. For better understanding of this phenomenon, we attempted to characterize the specificity of antibodies isolated from placentas of women with healthy pregnancy and pre-eclampsia (PE). It was found that: (1) the repertoire of placental antibodies is significantly less variable and qualitatively different from the peripheral blood; (2) with PE, the repertoire of placental antibodies is narrower than in healthy pregnancy; (3) some antibodies are found almost exclusively in the placenta, and some - only in the placenta of healthy women.
妊娠中免疫耐受的一个可能机制是产生阻断抗体，这些抗体存在于胎盘内，保护胎儿同种异体细胞免受母体免疫系统的攻击。它们的表位特异性以及被其掩盖的生物分子的性质尚不清楚。为了更好地理解这一现象，我们试图描述来自健康妊娠和子痫前期（PE）孕妇胎盘的抗体的特异性。结果发现：（1）胎盘抗体的 repertoire 明显变化较小，与外周血不同；（2）PE 时，胎盘抗体的 repertoire 比健康妊娠时更窄；（3）一些抗体几乎只存在于胎盘，而一些抗体仅存在于健康妇女的胎盘。
