一种新型抗菌酪氨酸衍生物，具有来自该真菌的天然前所未有的吗啉-2,3-二酮结构单元。
A novel antibacterial tyroscherin derivative with a natural unprecedented morpholine-2, 3-dione structural unit from the fungus .
作者信息
Chen Ruolan, Li Ziyang, Qin Chan, Lu Peijun, Lin Jiaru, Zheng Wenxu, Xiong Yahong, Li Chunyuan
机构信息
Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, China.
出版信息
Nat Prod Res. 2022 Dec;36(23):5977-5983. doi: 10.1080/14786419.2022.2050228. Epub 2022 Mar 12.
A novel tyroscherin derivative named pseudallecin A () with a natural unprecedented morpholine-2, 3-dione structural unit, and a new biogenic synthesis related organic acid named pseudallecin B () were purified from a symbiotic fungus derived from . Their structures were elucidated via spectroscopic analyses and ECD calculation. Pseudallecin A exhibited strong inhibitory activities against both Gram-positive and Gram-negative .
从源自[具体来源]的一种共生真菌中纯化得到了一种名为假阿莱辛A（）的新型酪丝菌素衍生物，其具有天然的前所未有的吗啉-2,3-二酮结构单元，以及一种新的与生物合成相关的有机酸假阿莱辛B（）。通过光谱分析和电子圆二色光谱（ECD）计算阐明了它们的结构。假阿莱辛A对革兰氏阳性菌和革兰氏阴性菌均表现出强烈的抑制活性。
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