Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Member of Interactive Dermatology Research group, Egypt.
Dermatol Ther. 2022 Jun;35(6):e15440. doi: 10.1111/dth.15440. Epub 2022 Apr 9.
Treatment of recalcitrant plantar warts represent a highly challenging issue for both patients and physicians. Candida antigen and purified protein derivative (PPD) have shown promising efficacy in the treatment of warts, however no previous studies have compared both antigens for recalcitrant plantar warts. To assess the efficacy and safety of intralesional Candida antigen versus intralesional PPD in the management of recalcitrant plantar warts. The study included 120 adult patients with multiple recalcitrant plantar warts. They were randomly assigned to one of three groups; Candida antigen, PPD, or normal saline. Injections into the largest wart were repeated every 2 weeks until clearance or for a maximum of five sessions. Complete wart clearance was reported in 33 patients (82.5%) of the Candida antigen group, in 22 patients (55.6%) of the PPD group, and in one patient (5%) of the control saline group. A statistically significant difference was found between the studied groups in favor of Candida antigen. Adverse effects were mild and insignificant in the three groups. Intralesional antigen immunotherapy by Candida antigen or PPD is a promising, safe, and cost-effective therapeutic option for multiple recalcitrant plantar warts, with statistically significant superiority of Candida antigen.
治疗顽固性足底疣对患者和医生来说都是一个极具挑战性的问题。 抗原和纯化蛋白衍生物（PPD）已显示出在治疗疣方面的良好疗效，但以前没有研究比较过这两种抗原治疗顽固性足底疣的效果。 评估抗原与 PPD 在治疗顽固性足底疣中的疗效和安全性。 该研究纳入了 120 例患有多发性顽固性足底疣的成年患者。 他们被随机分为三组：抗原、PPD 或生理盐水。 对最大的疣进行注射，每 2 周重复一次，直到清除或最多进行 5 次。 在抗原组中，33 例患者（82.5%）完全清除了疣，在 PPD 组中，22 例患者（55.6%）完全清除了疣，在对照组中，1 例患者（5%）完全清除了疣。 研究组之间存在统计学显著差异，抗原组的效果更好。 三组的不良反应均轻微且无统计学意义。 抗原或 PPD 的抗原免疫疗法是一种有前途、安全且具有成本效益的治疗多发性顽固性足底疣的方法，抗原的统计学优势显著。
