Ganer Herman Hadas, Mizrachi Yossi, Alon Ayala Shevach, Farhadian Yasmin, Gluck Ohad, Bar Jacob, Kovo Michal, Raziel Arieh
In-Vitro Fertilization Unit, The Edith Wolfson Medical Center, Holon, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Obstetrics & Gynecology, The Edith Wolfson Medical Center, Holon, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Reprod Sci. 2022 May;29(5):1644-1650. doi: 10.1007/s43032-021-00570-x. Epub 2022 Mar 14.
We aimed to compare obstetric and perinatal outcomes of in vitro fertilization (IVF) pregnancies following fresh and frozen embryo transfer (FET). This was a historic cohort of deliveries between November 2008 and January 2020 at a single university hospital, in which each fresh transfer IVF pregnancy was matched to a FET pregnancy by the same woman (1:1 ratio). We included live singleton deliveries (> 24 weeks of gestation) and excluded pregnancies following egg donation. The primary outcome was birthweight, and secondary outcomes were small for gestational age (SGA) neonates and preterm birth (PTB). A total of 107 fresh transfer pregnancies were matched to 107 FET pregnancies, in the same women. Mean maternal age was lower in the fresh transfer group compared to the FET group (30.4 vs. 32.5 years, p < 0.001). A higher rate of nulliparity was noted in fresh transfer pregnancies (64.5% vs. 12.1%, p < 0.001). Mean birthweight was non-significant between the groups (p = 0.13), and the rates of low birthweight and small for gestational age neonates did not differ between the groups. Preterm deliveries occurred in 10.3% and 9.3% of fresh transfer and FET pregnancies respectively, p = 0.79. On multivariate linear regression analysis, the type of embryo transfer-FET or fresh-was not independently associated with birthweight, after adjustment for women's age, nulliparity, and BMI. IVF pregnancies following fresh and FET entailed the same obstetric and perinatal outcomes when compared in the same women.
我们旨在比较新鲜胚胎移植（FET）和冷冻胚胎移植后的体外受精（IVF）妊娠的产科和围产期结局。这是一个历史性队列研究，研究对象为2008年11月至2020年1月在一家大学医院分娩的产妇，其中每例新鲜胚胎移植的IVF妊娠均与同一名女性的FET妊娠进行匹配（1:1比例）。我们纳入了单胎活产（妊娠>24周），并排除了卵子捐赠后的妊娠。主要结局为出生体重，次要结局为小于胎龄（SGA）新生儿和早产（PTB）。共有107例新鲜胚胎移植妊娠与107例FET妊娠在同一名女性中进行了匹配。与FET组相比，新鲜胚胎移植组的平均产妇年龄较低（30.4岁 vs. 32.5岁，p<0.001）。新鲜胚胎移植妊娠的初产妇比例更高（64.5% vs. 12.1%，p<0.001）。两组之间的平均出生体重无显著差异（p = 0.13），低出生体重和小于胎龄新生儿的发生率在两组之间也无差异。新鲜胚胎移植和FET妊娠的早产发生率分别为10.3%和9.3%，p = 0.79。在多变量线性回归分析中，在调整了女性年龄、初产妇情况和BMI后，胚胎移植类型（FET或新鲜胚胎移植）与出生体重无独立相关性。在同一名女性中比较时，新鲜胚胎移植和FET后的IVF妊娠具有相同的产科和围产期结局。
