Rikans L E
Life Sci. 1986 Sep 22;39(12):1027-36. doi: 10.1016/0024-3205(86)90193-1.
Drug effects are influenced by physiologic and pathologic changes that occur as a consequence of aging. The elderly may be more disposed to drug-induced nutrient depletion because of chronic illness, inadequate diet and long-term drug use. Digoxin, isoniazid, corticosteroids, diuretics and psychoactive agents pose special hazards to the nutritional status of elderly patients. On the other hand, dietary factors, such as protein levels or vitamin deficiencies, may be important determinants of age-related changes in drug disposition or toxicity.
药物效应会受到因衰老而发生的生理和病理变化的影响。由于慢性病、饮食不足和长期用药，老年人可能更容易出现药物引起的营养缺乏。地高辛、异烟肼、皮质类固醇、利尿剂和精神活性药物对老年患者的营养状况构成特殊风险。另一方面，饮食因素，如蛋白质水平或维生素缺乏，可能是药物处置或毒性方面与年龄相关变化的重要决定因素。
