Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, NanChang, China.
Drug Dev Ind Pharm. 2021 Nov;47(11):1700-1712. doi: 10.1080/03639045.2022.2053985. Epub 2022 Mar 25.
Nanocrystal technology is a new way to increase the solubility and bioavailability of poorly soluble drugs. As an intermediate preparation technology, nanocrystals are widely used in drug delivery for oral, venous, percutneous and inhalation administration, which exhibits a broad application prospect. By referring to the domestic anforeign literatures, this paper mainly reviews the preparation methods of nanocrystals for poorly soluble natural products and its application in the mucosal delivery for skin, eye, oral cavity and nasal cavity. This can provide the reference for the research and development of nanocrystal technology in natural product preparations.
纳米晶体技术是提高难溶性药物溶解度和生物利用度的新方法。作为一种中间制剂技术，纳米晶体广泛应用于口服、静脉、经皮和吸入给药的药物传递系统，具有广阔的应用前景。本文通过查阅国内外文献，主要综述了难溶性天然产物纳米晶体的制备方法及其在皮肤、眼部、口腔和鼻腔黏膜给药中的应用，为天然药物制剂中纳米晶体技术的研究与开发提供参考。
