• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection.

作者信息

Cong Mengqing, Yang Yunru, Tong Haiyang, Shimu Ajmeri Sultana, Wang Baolong, Li Qing, Li Fengyin, Yang Yi, Jin Tengchuan, Li Bofeng

机构信息

Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.

出版信息

Signal Transduct Target Ther. 2022 Mar 14;7(1):84. doi: 10.1038/s41392-022-00937-9.

DOI:10.1038/s41392-022-00937-9
PMID:35288536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8918896/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53f/8921198/4465f489e1e1/41392_2022_937_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53f/8921198/4465f489e1e1/41392_2022_937_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53f/8921198/4465f489e1e1/41392_2022_937_Fig1_HTML.jpg

相似文献

1
3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection.三剂重组刺突蛋白（RBD）疫苗足以引发针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的持久记忆反应。
Signal Transduct Target Ther. 2022 Mar 14;7(1):84. doi: 10.1038/s41392-022-00937-9.
2
A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation.一种新型针对 SARS-CoV-2 的 DNA 疫苗，编码一种嵌合蛋白，由其受体结合域（RBD）与乙型肝炎病毒前 S1 区的氨基末端融合，该嵌合蛋白带有 W4P 突变。
Front Immunol. 2021 Feb 26;12:637654. doi: 10.3389/fimmu.2021.637654. eCollection 2021.
3
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.一种针对严重急性呼吸综合征冠状病毒 2 刺突蛋白 RBD 的疫苗可诱导保护性免疫。
Nature. 2020 Oct;586(7830):572-577. doi: 10.1038/s41586-020-2599-8. Epub 2020 Jul 29.
4
Recombinant Expressing SARS-CoV-2 Receptor-Binding Domain as a Vaccine Candidate Against SARS-CoV-2 Infections.表达严重急性呼吸综合征冠状病毒2受体结合域的重组体作为抗严重急性呼吸综合征冠状病毒2感染的候选疫苗。
Front Immunol. 2021 Aug 27;12:712274. doi: 10.3389/fimmu.2021.712274. eCollection 2021.
5
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2.单剂 mRNA 疫苗为 hACE2 转基因小鼠提供了针对 SARS-CoV-2 的长期保护。
Nat Commun. 2021 Feb 3;12(1):776. doi: 10.1038/s41467-021-21037-2.
6
High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine Recipients.新型冠状病毒刺突蛋白受体结合域线性表位在 COVID-19 mRNA 疫苗接种者中的高分辨率线性表位作图。
Microbiol Spectr. 2021 Dec 22;9(3):e0096521. doi: 10.1128/Spectrum.00965-21. Epub 2021 Nov 10.
7
Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19.作为针对冠状病毒传染病（COVID-19）的异源人类疫苗，开发 SARS-CoV 受体结合域（RBD）重组蛋白的潜力。
Hum Vaccin Immunother. 2020 Jun 2;16(6):1239-1242. doi: 10.1080/21645515.2020.1740560. Epub 2020 Apr 16.
8
Elicitation of Broadly Neutralizing Antibodies against B.1.1.7, B.1.351, and B.1.617.1 SARS-CoV-2 Variants by Three Prototype Strain-Derived Recombinant Protein Vaccines.三种原型株衍生重组蛋白疫苗对 B.1.1.7、B.1.351 和 B.1.617.1 变异 SARS-CoV-2 诱导产生广谱中和抗体。
Viruses. 2021 Jul 22;13(8):1421. doi: 10.3390/v13081421.
9
Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta Variant.不同佐剂对基于蛋白质的亚单位疫苗引发的针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其德尔塔变种的免疫反应的影响。
Viruses. 2022 Feb 28;14(3):501. doi: 10.3390/v14030501.
10
Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting.在真实环境中评估灭活 COVID-19 疫苗诱导的 SARS-CoV-2 特异性体液和细胞免疫应答的特征。
Front Immunol. 2021 Dec 22;12:802858. doi: 10.3389/fimmu.2021.802858. eCollection 2021.

引用本文的文献

1
Activation and induction of antigen-specific T follicular helper cells play a critical role in recombinant SARS-CoV-2 RBD vaccine-induced humoral responses.抗原特异性滤泡辅助性T细胞的激活和诱导在重组SARS-CoV-2 RBD疫苗诱导的体液免疫反应中起关键作用。
Mol Biomed. 2023 Oct 19;4(1):34. doi: 10.1186/s43556-023-00145-z.
2
An intranasal vaccine comprising SARS-CoV-2 spike receptor-binding domain protein entrapped in mannose-conjugated chitosan nanoparticle provides protection in hamsters.一种鼻腔内疫苗，包含 SARS-CoV-2 刺突受体结合域蛋白，被包裹在甘露糖修饰壳聚糖纳米颗粒中，可在仓鼠中提供保护。
Sci Rep. 2023 Jul 26;13(1):12115. doi: 10.1038/s41598-023-39402-0.
3

本文引用的文献

1
The biological and clinical significance of emerging SARS-CoV-2 variants.新兴 SARS-CoV-2 变体的生物学和临床意义。
Nat Rev Genet. 2021 Dec;22(12):757-773. doi: 10.1038/s41576-021-00408-x. Epub 2021 Sep 17.
2
COVID-19 vaccines: Keeping pace with SARS-CoV-2 variants.COVID-19 疫苗：紧跟 SARS-CoV-2 变异株。
Cell. 2021 Sep 30;184(20):5077-5081. doi: 10.1016/j.cell.2021.09.010. Epub 2021 Sep 17.
3
Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials.
Developing Next-Generation Protein-Based Vaccines Using High-Affinity Glycan Ligand-Decorated Glyconanoparticles.
利用高亲和力糖基配体修饰的糖纳米粒子开发下一代基于蛋白质的疫苗。
Adv Sci (Weinh). 2023 Jan;10(2):e2204598. doi: 10.1002/advs.202204598. Epub 2022 Nov 18.
Sf9 细胞重组 COVID-19 疫苗在 18 岁及以上健康人群中的安全性和免疫原性：两项单中心、随机、双盲、安慰剂对照、1 期和 2 期临床试验。
Signal Transduct Target Ther. 2021 Jul 15;6(1):271. doi: 10.1038/s41392-021-00692-3.
4
Will SARS-CoV-2 variants of concern affect the promise of vaccines?高关注变异株会影响疫苗的效果吗？
Nat Rev Immunol. 2021 Jun;21(6):340-341. doi: 10.1038/s41577-021-00556-5.
5
Memory B cells.记忆 B 细胞。
Nat Rev Immunol. 2015 Mar;15(3):149-59. doi: 10.1038/nri3802. Epub 2015 Feb 13.
6
Lifetime of plasma cells in the bone marrow.骨髓中浆细胞的寿命。
Nature. 1997 Jul 10;388(6638):133-4. doi: 10.1038/40540.