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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.代谢状态调控的内皮细胞-脂肪细胞细胞外囊泡轴
Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4.
2
The old and new biochemistry of polyamines.多胺的新旧生物化学。
Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2053-2068. doi: 10.1016/j.bbagen.2018.06.004. Epub 2018 Jun 8.
3
Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis.精脒/精胺 N1-乙酰基转移酶介导的多胺分解代谢调节米色脂肪细胞的生成。
Metabolism. 2018 Aug;85:298-304. doi: 10.1016/j.metabol.2018.04.007. Epub 2018 Apr 30.
4
Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase.他莫昔芬对脂肪细胞谱系追踪的影响:脂肪生成诱导剂及Cre重组酶核转位的延长
Mol Metab. 2015 Aug 29;4(11):771-8. doi: 10.1016/j.molmet.2015.08.004. eCollection 2015 Nov.
5
Dual Regulatory Role of Polyamines in Adipogenesis.多胺在脂肪生成中的双重调节作用。
J Biol Chem. 2015 Nov 6;290(45):27384-27392. doi: 10.1074/jbc.M115.686980. Epub 2015 Sep 22.
6
The cell biology of fat expansion.脂肪扩张的细胞生物学
J Cell Biol. 2015 Mar 2;208(5):501-12. doi: 10.1083/jcb.201409063.
7
Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice.外源施用精胺可改善小鼠的葡萄糖利用并降低体重。
Eur J Pharmacol. 2014 Apr 15;729:94-9. doi: 10.1016/j.ejphar.2014.01.073. Epub 2014 Feb 13.
8
Adipose tissue remodeling and obesity.脂肪组织重构与肥胖。
J Clin Invest. 2011 Jun;121(6):2094-101. doi: 10.1172/JCI45887. Epub 2011 Jun 1.
9
An integrated view of insulin resistance and endothelial dysfunction.胰岛素抵抗与内皮功能障碍的综合观点。
Endocrinol Metab Clin North Am. 2008 Sep;37(3):685-711, ix-x. doi: 10.1016/j.ecl.2008.06.001.
10
Adipose tissue mass can be regulated through the vasculature.脂肪组织的质量可以通过脉管系统来调节。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10730-5. doi: 10.1073/pnas.162349799. Epub 2002 Jul 29.

一种能缩小脂肪的新信号。

A new signal that shrinks fat.

机构信息

Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Nat Metab. 2022 Mar;4(3):305-307. doi: 10.1038/s42255-022-00541-9.

DOI:10.1038/s42255-022-00541-9
PMID:35288723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8969187/
Abstract

Healthy white adipose tissue is dependent on proliferation of endothelial cells to maintain homeostasis or undergo expansion. A new study shows that endothelial cells communicate with adipocytes via polyamines to promote vascularization of adipose tissue, thereby reversing the metabolic effects of obesity.

摘要

健康的白色脂肪组织依赖于内皮细胞的增殖来维持其体内平衡或进行扩张。一项新的研究表明,内皮细胞通过多胺与脂肪细胞进行通讯,以促进脂肪组织的血管生成,从而逆转肥胖的代谢效应。