Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Cereb Cortex. 2022 Dec 20;33(2):486-496. doi: 10.1093/cercor/bhac079.
The spatiotemporal dynamics of interaction between slow (delta or infraslow) waves and fast (gamma) activities during wakefulness and sleep are yet to be elucidated in human electrocorticography (ECoG). We evaluated phase-amplitude coupling (PAC), which reflects neuronal coding in information processing, using ECoG in 11 patients with intractable focal epilepsy. PAC was observed between slow waves of 0.5-0.6 Hz and gamma activities, not only during light sleep and slow-wave sleep (SWS) but even during wakefulness and rapid eye movement (REM) sleep. While PAC was high over a large region during SWS, it was stronger in the posterior cortical region around the temporoparietal junction than in the frontal cortical region during REM sleep. PAC tended to be higher in the posterior cortical region than in the frontal cortical region even during wakefulness. Our findings suggest that the posterior cortical region has a functional role in REM sleep and may contribute to the maintenance of the dreaming experience.
在人类脑电皮质图（ECoG）中，清醒和睡眠期间慢波（德尔塔或 infraslow）与快波（伽马）活动之间相互作用的时空动力学仍有待阐明。我们使用 ECoG 评估了相位-振幅耦合（PAC），这反映了信息处理中的神经元编码，研究对象是 11 名患有难治性局灶性癫痫的患者。在轻度睡眠和慢波睡眠（SWS）期间，不仅在清醒和快速眼动（REM）睡眠期间，都观察到了 0.5-0.6 Hz 的慢波与伽马活动之间的 PAC。虽然在 SWS 期间，PAC 在较大区域内较高，但在 REM 睡眠期间，PAC 在颞顶联合区周围的皮质后区比在额皮质区更强。即使在清醒期间，PAC 在后皮质区也倾向于高于前皮质区。我们的发现表明，皮质后区在 REM 睡眠中具有功能作用，可能有助于维持梦境体验。
