当细胞周期蛋白依赖性激酶遇到病毒感染时，包括 SARS-CoV-2。
When cyclin-dependent kinases meet viral infections, including SARS-CoV-2.
机构信息
Center of Clinical Laboratory, The Fifth People's Hospital of Wuxi, Affiliated Hospital of Jiangnan University, Wuxi, China.
Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
出版信息
J Med Virol. 2022 Jul;94(7):2962-2968. doi: 10.1002/jmv.27719. Epub 2022 Mar 23.
Abstract
Cyclin-dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning CDKs' roles in viral infection and host antiviral defense are unknown. This minireview briefly overviews CDKs' functions and highlights the most recent discoveries of CDKs' emerging roles during viral infections, thereby providing a scientific and theoretical foundation for antiviral regulation and shedding light on developing novel drug targets and therapeutic strategies against viral infection.
摘要
细胞周期蛋白依赖性激酶（CDKs）是一类在细胞分裂和转录调控中起关键作用的蛋白激酶。最近的研究表明，CDKs 在各种病毒感染中起着至关重要的作用。然而，CDKs 在病毒感染和宿主抗病毒防御中的作用的分子机制尚不清楚。本文简要概述了 CDK 的功能，并重点介绍了 CDK 在病毒感染过程中作用的最新发现，为抗病毒调控提供了科学理论基础，并为开发针对病毒感染的新型药物靶点和治疗策略提供了思路。
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