Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
School of Health and Life Sciences, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
J Periodontol. 2022 Sep;93(9):1411-1420. doi: 10.1002/JPER.21-0575. Epub 2022 Apr 20.
Little is known about a synergistic effect of periodontitis and obesity on systemic biomarkers and a possible effect periodontal treatment may exert. This study aimed to evaluate the impact of periodontitis and periodontal treatment on systemic inflammation and metabolic profile in obese and non-obese rats.
Sixty male Wistar rats were randomly divided in six groups differentiated by diet and periodontal status: no periodontitis (G1 and G4), untreated ligature-induced periodontitis (G2 and G5), and treated ligature-induced periodontitis (G3 and G6). Groups G4, G5, and G6 were exposed to cafeteria diet to induce obesity. Periodontitis was induced by silk ligatures over 4 weeks (G2, G3, G5, and G6). Rats in G3 and G6 received scaling and root planing and were followed for additional 4 weeks. After sacrifice, serum levels of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-10, IL-17a, tumor necrosis factor alfa (TNF-α), glucose, triglycerides, and total cholesterol (TC) were compared between groups.
CRP was significantly higher in obese rats with than without periodontitis (G5 = 10.15 versus G4 = 4.47 μg/L, P = 0.01). No beneficial effects of periodontal treatment were observed for CRP levels, IL-6, IL-1β, IL-17a, and TNF-α, glucose and triglycerides. Treated periodontitis (G6) exhibited significantly lower TC than the periodontitis group (G5) in obese rats.
Periodontitis increased serum CRP in obese rats, indicating a synergistic role of periodontitis in the systemic inflammatory burden triggered by obesity. The treatment of induced periodontitis reduced TC levels in obese rats.
关于牙周炎和肥胖对全身生物标志物的协同作用以及牙周治疗可能产生的影响知之甚少。本研究旨在评估牙周炎和牙周治疗对肥胖和非肥胖大鼠全身炎症和代谢特征的影响。
60 只雄性 Wistar 大鼠随机分为 6 组，根据饮食和牙周状况进行区分：无牙周炎（G1 和 G4）、未治疗结扎诱导的牙周炎（G2 和 G5）和治疗结扎诱导的牙周炎（G3 和 G6）。G4、G5 和 G6 组暴露于自助餐厅饮食以诱导肥胖。4 周（G2、G3、G5 和 G6）用丝线结扎诱导牙周炎。G3 和 G6 组接受牙周洁治和根面平整，并进行额外的 4 周随访。处死大鼠后，比较各组大鼠血清 C 反应蛋白（CRP）、白细胞介素（IL）-1β、IL-6、IL-10、IL-17a、肿瘤坏死因子-α（TNF-α）、葡萄糖、甘油三酯和总胆固醇（TC）水平。
与无牙周炎（G4）的肥胖大鼠相比，有牙周炎（G5）的大鼠 CRP 显著升高（G5=10.15 比 G4=4.47μg/L，P=0.01）。牙周治疗对 CRP 水平、IL-6、IL-1β、IL-17a 和 TNF-α、葡萄糖和甘油三酯无有益作用。与牙周炎组（G5）相比，治疗性牙周炎（G6）在肥胖大鼠中 TC 水平显著降低。
牙周炎增加了肥胖大鼠血清 CRP 水平，表明牙周炎在肥胖引发的全身炎症负担中起协同作用。诱导性牙周炎的治疗降低了肥胖大鼠的 TC 水平。
