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抵御高温:植物应激颗粒中的相分离

Beating the heat: Phase separation in plant stress granules.

作者信息

Allen Jeffrey R, Strader Lucia C

机构信息

Department of Biology, Duke University, Durham, NC, USA.

Department of Biology, Duke University, Durham, NC, USA.

出版信息

Dev Cell. 2022 Mar 14;57(5):563-565. doi: 10.1016/j.devcel.2022.02.012.

DOI:10.1016/j.devcel.2022.02.012
PMID:35290778
Abstract

Plants form stress granules made of RNA binding proteins and RNA in response to various stresses. In this issue of Developmental Cell, Zhu et al. identify two RNA-binding proteins, RBGD2/4, that phase, separate, and localize stress granules to promote heat stress tolerance.

摘要

植物在应对各种胁迫时会形成由RNA结合蛋白和RNA组成的应激颗粒。在本期《发育细胞》杂志中,朱等人鉴定出两种RNA结合蛋白RBGD2/4,它们通过相分离和定位应激颗粒来提高耐热性。

相似文献

1
Beating the heat: Phase separation in plant stress granules.抵御高温:植物应激颗粒中的相分离
Dev Cell. 2022 Mar 14;57(5):563-565. doi: 10.1016/j.devcel.2022.02.012.
2
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis.拟南芥中RBGD2/4的液-液相分离是耐热胁迫所必需的。
Dev Cell. 2022 Mar 14;57(5):583-597.e6. doi: 10.1016/j.devcel.2022.02.005. Epub 2022 Feb 28.
3
AtC3H18L is a stop-codon read-through gene and encodes a novel non-tandem CCCH zinc-finger protein that can form cytoplasmic foci similar to mRNP granules.AtC3H18L 是一个终止密码通读基因,编码一种新型非串联 CCCH 锌指蛋白,可形成类似于 mRNP 颗粒的细胞质焦点。
Biochem Biophys Res Commun. 2020 Jul 12;528(1):140-145. doi: 10.1016/j.bbrc.2020.05.081. Epub 2020 May 23.
4
Proteasome resides in and dismantles plant heat stress granules constitutively.蛋白酶体在植物热应激颗粒中存在并持续进行解体。
Mol Cell. 2024 Sep 5;84(17):3320-3335.e7. doi: 10.1016/j.molcel.2024.07.033. Epub 2024 Aug 21.
5
Plant stress granules and mRNA processing bodies are distinct from heat stress granules.植物应激颗粒和mRNA加工小体与热应激颗粒不同。
Plant J. 2008 Nov;56(4):517-30. doi: 10.1111/j.1365-313X.2008.03623.x. Epub 2008 Aug 6.
6
Stress granule formation is induced by a threshold temperature rather than a temperature difference in .应激颗粒的形成是由一个阈值温度而非温差诱导的。
J Cell Sci. 2018 Aug 20;131(16):jcs216051. doi: 10.1242/jcs.216051.
7
Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.在含有RNA结合蛋白的细胞质颗粒中鉴定连接斑蛋白桥粒芯蛋白3以及桥粒芯蛋白1和3向应激颗粒的募集。
Mol Biol Cell. 2006 Mar;17(3):1388-98. doi: 10.1091/mbc.e05-08-0708. Epub 2006 Jan 11.
8
The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor.冷诱导RNA结合蛋白通过一种甲基化依赖机制从细胞核迁移至细胞质应激颗粒,并作为一种翻译抑制因子发挥作用。
Exp Cell Res. 2007 Dec 10;313(20):4130-44. doi: 10.1016/j.yexcr.2007.09.017. Epub 2007 Sep 29.
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Tudor staphylococcal nuclease links formation of stress granules and processing bodies with mRNA catabolism in Arabidopsis.都铎葡萄球菌核酸酶将拟南芥中应激颗粒和加工小体的形成与mRNA分解代谢联系起来。
Plant Cell. 2015 Mar;27(3):926-43. doi: 10.1105/tpc.114.134494. Epub 2015 Mar 3.
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Recovery from heat, salt and osmotic stress in Physcomitrella patens requires a functional small heat shock protein PpHsp16.4.在石松中,从小热休克蛋白 PpHsp16.4 中恢复对热、盐和渗透胁迫的需要。
BMC Plant Biol. 2013 Nov 5;13:174. doi: 10.1186/1471-2229-13-174.

引用本文的文献

1
Impact of m6A modification and transcript quantity on mRNA composition in plant stress granules under hypoxia.缺氧条件下m6A修饰和转录本数量对植物应激颗粒中mRNA组成的影响
J Exp Bot. 2025 May 27;76(8):2338-2355. doi: 10.1093/jxb/eraf046.
2
Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence.拟南芥介体型半胱氨酸蛋白酶 MC1 定位于应激颗粒中,可清除蛋白质聚集体,并延缓衰老。
Plant Cell. 2023 Sep 1;35(9):3325-3344. doi: 10.1093/plcell/koad172.