Davidson Michael, Sebastian Sneha A, Benitez Yoanna, Desai Shreeya, Quinonez Jonathan, Ruxmohan Samir, Stein Joel D, Cueva Wilson
Pediatrics, Larkin Community Hospital, South Miami, USA.
Research, Larkin Community Hospital, South Miami, USA.
Cureus. 2022 Feb 2;14(2):e21840. doi: 10.7759/cureus.21840. eCollection 2022 Feb.
Fragile X syndrome (FXS) is noted to be the leading cause of inherited intellectual disabilities and is caused by expansive cytosine-guanine-guanine (CGG) trinucleotide repeats in the fragile X mental retardation 1 gene (FMR1). FXS can display a wide range of behavioral problems in addition to intellectual and developmental issues. Management of these problems includes both pharmacological and non-pharmacological options and research on these different management styles has been extensive in recent years. This narrative review aimed to collate recent evidence on the various management options of behavioral problems in FXS, including the pharmacological and non-pharmacological treatments, and also to provide a review of the newer avenues in the FXS treatment.
脆性X综合征(FXS)是遗传性智力残疾的主要原因,由脆性X智力低下1基因(FMR1)中胞嘧啶-鸟嘌呤-鸟嘌呤(CGG)三核苷酸重复序列扩展所致。除智力和发育问题外,FXS还可表现出广泛的行为问题。这些问题的管理包括药物和非药物选择,近年来对这些不同管理方式的研究广泛。本叙述性综述旨在整理FXS行为问题各种管理选择的最新证据,包括药物和非药物治疗,并对FXS治疗的新途径进行综述。