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一例累及宫颈的罕见慢性淋巴细胞白血病病例。

An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix.

作者信息

Hamer Jack, Alazizi Maher, Tahmasebi Farshad

机构信息

Obstetrics and Gynaecology, Walsall Manor Hospital, The Walsall Healthcare National Health Service Trust, Walsall, GBR.

Obstetrics and Gynaecology, Russells Hall Hospital, The Dudley Group National Health Service Foundation Trust, Dudley, GBR.

出版信息

Cureus. 2022 Feb 1;14(2):e21823. doi: 10.7759/cureus.21823. eCollection 2022 Feb.

Abstract

Chronic lymphocytic leukaemia (CLL) is a malignant monoclonal expansion of B lymphocytes, with accumulation of abnormal lymphocytes in the blood, bone marrow, spleen, lymph nodes and liver. It is mainly a disease of the elderly population. Though extra-nodal involvement is common, cervical and vulvovaginal involvement by CLL is particularly uncommon. In this case report, we discuss the case of cervical involvement of CLL in an 84-year-old patient who presented to rapid-access gynaecological clinic following concerns of persistent postmenopausal bleeding. Previously the patient was known to haematology with a well-controlled diagnosis of CLL since 2007. The initial examination was significant for an enlarged, irregular cervix, whereby a punch biopsy was then obtained. Histological analysis revealed evidence of CLL within the cervix.

摘要

慢性淋巴细胞白血病(CLL)是B淋巴细胞的恶性单克隆增殖,异常淋巴细胞在血液、骨髓、脾脏、淋巴结和肝脏中积聚。它主要是一种老年人群的疾病。虽然结外受累很常见,但CLL累及宫颈和外阴阴道尤其罕见。在本病例报告中,我们讨论了一名84岁患者CLL累及宫颈的病例,该患者因绝经后持续出血而就诊于快速通道妇科门诊。该患者自2007年以来一直患有CLL,此前血液科已对其进行了病情控制良好的诊断。初步检查发现宫颈肿大且形态不规则,随后进行了组织活检。组织学分析显示宫颈内存在CLL的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9819/8896842/c24c8e7e8bd2/cureus-0014-00000021823-i01.jpg

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