Vladutiu A O
Immunol Commun. 1978;7(4):371-82. doi: 10.3109/08820137809047623.
Cytotoxic T lymphocytes can eliminate cells infected with hepatitis B virus. A defect of T lymphocyte-mediated cytolysis seems to exist in chronic hepatitis B infection. T cell-mediated lysis is dependent on HLA antigens of the infected host and this may explain the increased or decreased frequency of particular HLA antigens in chronic carriers of hepatitis B virus. This virus may decrease the concentration of HLA antigens expressed on liver cells. Interferon increases the HLA antigen expression on T lymphocytes and hepatocytes, thereby enhancing T lymphocyte-mediate lysis of infected liver cells and elimination of the hepatitis B virus.
细胞毒性T淋巴细胞能够清除感染乙型肝炎病毒的细胞。在慢性乙型肝炎感染中似乎存在T淋巴细胞介导的细胞溶解缺陷。T细胞介导的细胞溶解取决于受感染宿主的HLA抗原，这可能解释了乙型肝炎病毒慢性携带者中特定HLA抗原频率的增加或减少。这种病毒可能会降低肝细胞上表达的HLA抗原浓度。干扰素可增加T淋巴细胞和肝细胞上的HLA抗原表达，从而增强T淋巴细胞介导的对受感染肝细胞的溶解作用以及乙型肝炎病毒的清除。
