School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province, China.
Jiangsu Key Laboratory for Design and Manufacture of Micro/Nano Biomedical Instruments Micro-Tech (Nanjing) Co., Ltd, Nanjing, Jiangsu Province, China.
Int J Numer Method Biomed Eng. 2022 May;38(5):e3592. doi: 10.1002/cnm.3592. Epub 2022 Mar 21.
A biliary stent is used to expand the bile duct during interventional treatment of biliary stricture. To reduce the complications after stent implantation, it is necessary to understand and improve the comprehensive performance of magnesium alloy biliary stents. In this study, at first, the mechanical performance of magnesium alloy biliary stent in bile ducts with different ellipticitiesis studied, and the influence of the ellipticity of bile duct on the interaction of the stent-bile duct coupling system is better understood. Proposed results show the increment of ellipticity of the bile duct will increase the difficulty of expanding the stent. Second, to improve the mechanical performance and degradation performance of the stent simultaneously, an optimal design method based on a zero-order algorithm is used to reduce the maximum equivalent stress on the stent effectively, to make the stress distribution more uniform, and to expand the bile duct of the lesion more effectively and uniformly. The results of this analysis and optimization are useful to predict the clinical effect of stents and to design and optimize stents for both bile duct and other non-vascular.
胆道支架用于在胆道狭窄的介入治疗中扩张胆管。为了减少支架植入后的并发症,有必要了解和提高镁合金胆道支架的综合性能。在这项研究中,首先研究了不同椭圆度胆管中镁合金胆道支架的力学性能,更好地了解了胆管椭圆度对支架-胆管耦合系统相互作用的影响。提出的结果表明,胆管椭圆度的增加会增加支架扩张的难度。其次,为了同时提高支架的力学性能和降解性能,采用基于零阶算法的优化设计方法,有效地降低了支架上的最大等效应力,使支架的应力分布更加均匀,更有效地、更均匀地扩张病变胆管。分析和优化的结果有助于预测支架的临床效果,并设计和优化胆管和其他非血管的支架。