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哪些 MRI 表现符合招募伴有轴性受累的银屑病关节炎患者的临床试验标准?

What Constitutes a Positive MRI for Clinical Trial Recruitment of Psoriatic Arthritis Patients With Axial Involvement?

机构信息

W.P. Maksymowych, FRCPC, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada;

M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Rheumatol. 2022 Jun;49(6 Suppl 1):72-74. doi: 10.3899/jrheum.211340. Epub 2022 Mar 15.

DOI:10.3899/jrheum.211340
PMID:35293333
Abstract

There has been a resurgence of interest in defining the axial inflammation component of psoriatic arthritis (PsA) since recent randomized controlled trials (RCTs) raised the possibility that this entity may respond differentially to therapeutics compared to patients with axial spondyloarthritis. A workshop was conducted during the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis annual meeting to review the literature on diagnosing PsA and to determine which criteria might be most appropriate. There was quite strong agreement that magnetic resonance imaging (MRI) had an important role to play in helping to define axial inflammation in PsA and that a data-driven methodology for generating optimal MRI quantitative cut-offs for lesions in the sacroiliac joints and/or spine that reflect imaging typical of axial inflammation in PsA would be most desirable.

摘要

自从最近的随机对照试验(RCT)提出这样一种可能性,即与患有中轴型脊柱关节炎的患者相比,这种实体可能对治疗有不同的反应以来,人们对定义银屑病关节炎(PsA)的轴向炎症成分重新产生了兴趣。在 2021 年银屑病和银屑病关节炎研究评估组年会上举办了一次研讨会,以回顾有关诊断 PsA 的文献,并确定哪些标准可能最合适。与会者非常一致地认为,磁共振成像(MRI)在帮助确定 PsA 的轴向炎症方面发挥着重要作用,并且为反映 PsA 中轴炎症的影像学特征的骶髂关节和/或脊柱病变生成最佳 MRI 定量截止值的基于数据的方法将是最理想的。

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引用本文的文献

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Imaging in psoriatic arthritis: established methods and emerging techniques.银屑病关节炎的影像学检查:既定方法与新兴技术
Ther Adv Musculoskelet Dis. 2024 Oct 16;16:1759720X241288060. doi: 10.1177/1759720X241288060. eCollection 2024.