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在机器人创面系统中测试含银胶状纤维敷料的流体处理动力学和耐久性。

Fluid Handling Dynamics and Durability of Silver-Containing Gelling Fiber Dressings Tested in a Robotic Wound System.

机构信息

At Tel Aviv University, Department of Biomedical Engineering, Tel Aviv, Israel, Aleksei Orlov, MSc; Adi Lustig, MSc; and Angela Grigatti, MSc, are Graduate Students at the research group of Professor Gefen; and Amit Gefen, PhD, is Professor of Biomedical Engineering and the Herbert J. Berman Chair in Vascular Bioengineering. Acknowledgment: This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 811965; project STINTS (Skin Tissue Integrity under Shear). This work was also partially supported by the Israeli Ministry of Science & Technology (Medical Devices Program grant no. 3-17421, awarded to Prof Amit Gefen in 2020) and by Mölnlycke Health Care (Gothenburg, Sweden). The authors thank Ms Orel Belo, the Laboratory Engineer at the Gefen Laboratory, for supporting the experimental work. The authors have disclosed no other financial relationships related to this article. Submitted July 23, 2021; accepted in revised form November 1, 2021; published online ahead of print March 14, 2022.

出版信息

Adv Skin Wound Care. 2022 Jun 1;35(6):326-334. doi: 10.1097/01.ASW.0000823972.16446.ff.

Abstract

OBJECTIVE

To develop a robotic phantom system containing multiple simulated wound replicates to determine the synergy in fluid absorbency and retention (sorptivity) performances and the post-simulated-use mechanical durability of silver-containing gelling fiber primary dressings when used with a secondary dressing, as per clinical practice.

METHODS

Using a robotic system containing six identical wound simulators, the authors tested the sorptivity performances of the Exufiber Ag + (Mölnlycke Health Care, Gothenburg, Sweden) primary dressing (ExAg-polyvinyl alcohol [PVA]) against a market-leading comparator product, when used with a secondary foam dressing. The durability of the primary dressings after simulated use was further investigated through tensile mechanical testing.

RESULTS

The ExAg-PVA primary dressing delivered greater fluid amounts for absorbency and retention by the secondary foam dressing, approximately 2- and 1.5-fold more than the comparator dressing pair after 10 and 15 hours, respectively. The ExAg-PVA dressing was also substantially less sensitive to the direction of pulling forces and, accordingly, exhibited post-use mechanical strength that was approximately four and six times greater than that of the other primary dressing (when the latter dressing was tested out-of-alignment with its visible seams) after 10 and 15 hours, respectively.

CONCLUSIONS

The dynamics of the sorptivity and fluid sharing between primary and secondary dressings and the effect of directional preference of strength of the primary dressings for adequate durability, resulting in safe post-use removals, have been described. The comparative quantification of these capabilities should help clinical and nonclinical decision-makers select dressings that best meet their patient needs.

摘要

目的

开发一种包含多个模拟伤口复制品的机器人模型系统,以确定在临床实践中与二级敷料一起使用时,含银水凝胶纤维初级敷料的流体吸收和保留(吸水性)性能协同作用以及模拟使用后的机械耐用性。

方法

作者使用包含六个相同伤口模拟器的机器人系统,测试了 Exufiber Ag+(Mölnlycke Health Care,哥德堡,瑞典)初级敷料(ExAg-聚乙烯醇[PVA])的吸水性性能,与市场领先的对照产品进行对比,当与二级泡沫敷料一起使用时。通过拉伸机械测试进一步研究了初级敷料模拟使用后的耐用性。

结果

ExAg-PVA 初级敷料通过二级泡沫敷料提供了更多的吸收和保留量,在 10 小时和 15 小时后,分别比对照敷料对多约 2 倍和 1.5 倍。ExAg-PVA 敷料对拉力方向的敏感性也大大降低,因此,在 10 小时和 15 小时后,其使用后的机械强度分别比其他初级敷料高约 4 倍和 6 倍(当后者的敷料与可见缝线不对齐进行测试时)。

结论

描述了初级和二级敷料之间吸水性和流体共享的动力学以及初级敷料强度的方向偏好对足够耐用性的影响,从而实现安全的使用后去除。这些能力的比较量化应该有助于临床和非临床决策者选择最符合患者需求的敷料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a04b/9119404/38f9c306b4d9/nsw-35-326-g001.jpg

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