McClane Jenna, Chawla Anjulika, Welch Jennifer J G
Department of Pediatrics, Brown University and Hasbro Children's Hospital, Providence, Rhode Island, USA.
Division of Hematology Oncology, Department of Pediatrics, Brown University and Hasbro Children's Hospital, Providence, Rhode Island, USA.
Pediatr Blood Cancer. 2022 Jun;69(6):e29664. doi: 10.1002/pbc.29664. Epub 2022 Mar 16.
Relapsed central nervous system (CNS) leukemia presents a therapeutic challenge to pediatric oncologists. Systemic monoclonal antibody therapy has shown recent promise in patients with relapsed acute lymphoblastic leukemia, however its effect on CNS disease in this population is not well established. We describe a case of multiply relapsed and refractory CNS leukemia in an adolescent patient who responded to the intra-CNS delivery of rituximab (anti-CD20) and epratuzumab (anti-CD22) therapy, demonstrating the practical use and potential efficacy of a novel route of monoclonal antibody administration in difficult-to-treat CNS leukemia.
复发性中枢神经系统（CNS）白血病给儿科肿瘤学家带来了治疗挑战。全身单克隆抗体疗法最近在复发性急性淋巴细胞白血病患者中显示出前景，然而其对该人群中枢神经系统疾病的影响尚未明确。我们描述了一例青少年患者，其患有多次复发且难治的中枢神经系统白血病，对中枢神经系统内给予利妥昔单抗（抗CD20）和依帕珠单抗（抗CD22）治疗有反应，证明了单克隆抗体给药新途径在难治性中枢神经系统白血病中的实际应用和潜在疗效。
