Manchester Metropolitan University Institute of Sport, Manchester, UK.
Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
Eur J Sport Sci. 2023 May;23(5):726-735. doi: 10.1080/17461391.2022.2053752. Epub 2022 Mar 29.
There is growing evidence of genetic contributions to tendon and ligament pathologies. Given the high incidence and severity of tendon and ligament injuries in elite rugby, we studied whether 13 gene polymorphisms previously associated with tendon/ligament injury were associated with elite athlete status. Participants from the RugbyGene project were 663 elite Caucasian male rugby athletes (RA) (mean (standard deviation) height 1.85 (0.07) m, mass 101 (12) kg, age 29 (7) yr), including 558 rugby union athletes (RU) and 105 rugby league athletes. Non-athletes (NA) were 909 Caucasian men and women (56% female; height 1.70 (0.10) m, mass 72 (13) kg, age 41 (23) yr). Genotypes were determined using TaqMan probes and groups compared using Χ and odds ratio (OR). rs8090 AA genotype was more frequent in RA (27%) than NA (23%; = 0.006). rs1800255 A allele was more frequent in RA (26%) than NA (23%) due to a greater frequency of GA genotype (39% vs 33%). For rs4919510, RA had 1.7 times the odds of carrying the CC genotype compared to NA. rs591058 TT genotype was less common in RA (25.1%) than NA (31.2%; < 0.04). For rs4660148, RA had 1.6 times the odds of carrying the TT genotype compared to NA. It appears that elite rugby athletes have an inherited advantage that contributes to their elite status, possibly via resistance to soft tissue injury. These data may, in future, assist personalised management of injury risk amongst athletes. The elite rugby athletes we studied had differing genetic characteristics to non-athletes regarding genetic variants previously associated with soft-tissue injury risk. rs8090, rs1800255, rs4919510, rs591058 and rs4660148 were all associated with elite status in rugby.We propose that elite rugby athletes might possess an inherited resistance to soft tissue injury, which has enabled them to achieve elite status despite exposure to the high-risk environment of elite rugby.
越来越多的证据表明遗传因素与肌腱和韧带疾病有关。鉴于精英橄榄球运动员中肌腱和韧带损伤的高发率和严重性，我们研究了以前与肌腱/韧带损伤相关的 13 种基因多态性是否与精英运动员地位相关。RugbyGene 项目的参与者包括 663 名精英白种男性橄榄球运动员（RA）（平均（标准差）身高 1.85（0.07）米，体重 101（12）公斤，年龄 29（7）岁），包括 558 名橄榄球联盟运动员（RU）和 105 名橄榄球联盟运动员。非运动员（NA）为 909 名白种男女（56%为女性；身高 1.70（0.10）米，体重 72（13）公斤，年龄 41（23）岁）。使用 TaqMan 探针确定基因型，并用Χ和优势比（OR）比较组。rs8090AA 基因型在 RA（27%）中比 NA（23%； = 0.006）更常见。rs1800255A 等位基因在 RA（26%）中比 NA（23%）更常见，这是由于 GA 基因型的频率更高（39%比 33%）。对于 rs4919510，与 NA 相比，RA 携带 CC 基因型的几率高出 1.7 倍。rs591058TT 基因型在 RA（25.1%）中比 NA（31.2%）少见； < 0.04）。对于 rs4660148，与 NA 相比，RA 携带 TT 基因型的几率高出 1.6 倍。似乎精英橄榄球运动员具有遗传优势，这有助于他们的精英地位，可能是通过抵抗软组织损伤。这些数据将来可能有助于运动员受伤风险的个性化管理。与以前与软组织损伤风险相关的遗传变异相比，我们研究的精英橄榄球运动员与非运动员在遗传特征上存在差异。rs8090、rs1800255、rs4919510、rs591058 和 rs4660148 均与橄榄球运动中的精英地位相关。我们提出，精英橄榄球运动员可能具有对软组织损伤的遗传抗性，这使他们能够在精英橄榄球的高风险环境中保持精英地位。
