Department of Medicine, Renal Unit, IBB Specialist Hospital, Minna; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.
Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.
Niger J Clin Pract. 2022 Mar;25(3):226-230. doi: 10.4103/njcp.njcp_234_19.
Data on iron status are generally less readily available in pre-dialysis chronic kidney disease (CKD) patients than in the hemodialysis population. In Nigeria, little is known about iron indices in patients with CKD.
The aim of this study was to evaluate the iron status among anemic pre-dialysis patients with CKD.
Using a cross-sectional study design, we evaluated serum ferritin and transferrin saturation (TSAT) among 63 pre-dialysis CKD patients with anemia attending our outpatient nephrology clinic. CKD was defined as a glomerular filtration rate less than 60 ml/min/1.73 m for 3 months or more, while anemia was defined as a hemoglobin concentration (Hb) less than 11 g/dl.
The mean age of the study participants was 52.5 ± 12.7 years and 33 (52.4%) of the patients were females. The most common causes of CKD were hypertension (44.4%) and diabetic nephropathy (30.6%). The mean Hb, mean serum ferritin, and mean TSAT were 9.2 ± 1.1 g/dl, 106.6 ± 72.7 ng/ml, and 24.3% ± 7.9%, respectively. There was no significant difference in median ferritin (91[interquartile range: 54-133] ng/ml versus 106 [interquartile range: 45-151; P=0.75) and mean TSAT (24.9 ± 7.2 % versus 23.8 ± 7.7 %; P=0.54) between male and female study participants; Half (50.8%) of the study participants had absolute iron deficiency (serum ferritin <100 ng/ml) and 6.3% had functional iron deficiency (ferritin >100 ng/ml and TSAT <20%).
Iron deficiency is common among anemic adult Nigerian pre-dialysis CKD patients. Results of iron studies should guide therapy when correcting anemia in these patients.
与血液透析患者相比，一般来说，铁状态数据在透析前慢性肾脏病（CKD）患者中较难获得。在尼日利亚，人们对 CKD 患者的铁指标知之甚少。
本研究旨在评估贫血透析前 CKD 患者的铁状态。
采用横断面研究设计，我们评估了 63 名在我院门诊肾病科就诊的贫血透析前 CKD 患者的血清铁蛋白和转铁蛋白饱和度（TSAT）。CKD 定义为肾小球滤过率（GFR）<60 ml/min/1.73 m 持续 3 个月以上，而贫血定义为血红蛋白（Hb）浓度<11 g/dl。
研究参与者的平均年龄为 52.5±12.7 岁，33 名（52.4%）患者为女性。CKD 的最常见病因是高血压（44.4%）和糖尿病肾病（30.6%）。平均 Hb、平均血清铁蛋白和平均 TSAT 分别为 9.2±1.1 g/dl、106.6±72.7ng/ml 和 24.3%±7.9%。男性和女性研究参与者的中位铁蛋白（91[四分位距：54-133]ng/ml 与 106 [四分位距：45-151；P=0.75]和平均 TSAT（24.9±7.2%与 23.8±7.7%；P=0.54）无显著差异；一半（50.8%）的研究参与者存在绝对铁缺乏（血清铁蛋白<100ng/ml），6.3%存在功能性铁缺乏（铁蛋白>100ng/ml 且 TSAT<20%）。
在尼日利亚成年透析前 CKD 贫血患者中，铁缺乏很常见。在纠正这些患者的贫血时，铁研究的结果应指导治疗。
