用于基于片段的碳酸酐酶抑制剂药物发现的多样化取代磺胺：合成和抑制谱。
Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile.
机构信息
Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
出版信息
J Enzyme Inhib Med Chem. 2022 Dec;37(1):857-865. doi: 10.1080/14756366.2022.2051023.
A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms CA IX and XII was co-crystalized with CA II showing significant potential for fragment periphery evolution fragment growth and linking. These opportunities will be identified in the future the screening of this fragment structure for co-operative carbonic anhydrase binding with other structurally diverse fragments.[Figure: see text].
已经合成了一系列磺胺片段，并对其进行了人类碳酸酐酶抑制活性的研究。其中一个片段对与癌症相关的同工酶 CAIX 和 CA XII 表现出更高的选择性，与 CA II 共结晶显示出了对片段外围进化、片段生长和连接具有显著潜力。未来将确定这些机会，并对该片段结构进行筛选，以寻找与其他结构多样的片段的协同碳酸酐酶结合。[图：见正文]。
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