Karni Arnon, Ben Noon Gil, Shiner Tamara, Vigiser Ifat, Kolb Hadar, Regev Keren
Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sci Rep. 2022 Mar 16;12(1):4555. doi: 10.1038/s41598-022-08565-7.
The prevalence and severity of Multiple Sclerosis (MS) varies across different ethnicities, with a tendency to a more severe phenotype in non-Caucasian populations. Our objective was to evaluate the differences in disease phenotype between Ashkenazi Jewish and Non-Ashkenazi Jewish patients in Israel. We conducted a single center retrospective cohort study in which subjects were assigned to Ashkenazi or Non-Ashkenazi groups according to self-reported ancestry and disease severity was assessed using the expanded disability status (EDSS), MS severity score (MSSS), progression index (PI) and MRI metrics. 330 Ashkenazi Jewish (AJ) and 207 Non-Ashkenazi Jewish patients (Non-AJ) were included. Non-AJ had a younger age of disease onset (32.7 years vs. 35.7 years, p = 0.05), with a lower proportion of females (62.3% vs. 73.3%, p = 0.01). These differences were maintained within the subgroup of Israeli native patients. Ethnicity was a significant predictor of MSSS (β = 0.601, p = 0.003), with a higher estimate than that of other epidemiological factors. To conclude, Non-AJ patients had an earlier age of onset and a more disabling disease as well as having a more balanced female to male ratio compared to AJ patients. These findings demonstrate variability of disease phenotype within Caucasian patient's dependent on their ethnicity despite equivalent access to healthcare services.
多发性硬化症（MS）的患病率和严重程度在不同种族间存在差异，非白种人群往往表现出更严重的疾病表型。我们的目的是评估以色列阿什肯纳兹犹太人和非阿什肯纳兹犹太患者之间疾病表型的差异。我们进行了一项单中心回顾性队列研究，根据自我报告的血统将受试者分为阿什肯纳兹组或非阿什肯纳兹组，并使用扩展残疾状态量表（EDSS）、MS严重程度评分（MSSS）、进展指数（PI）和MRI指标评估疾病严重程度。研究纳入了330名阿什肯纳兹犹太（AJ）患者和207名非阿什肯纳兹犹太患者（非AJ）。非AJ患者的发病年龄较轻（32.7岁对35.7岁，p = 0.05），女性比例较低（62.3%对73.3%，p = 0.01）。这些差异在以色列本土患者亚组中依然存在。种族是MSSS的重要预测因素（β = 0.601，p = 0.003），其估计值高于其他流行病学因素。总之，与AJ患者相比，非AJ患者发病年龄更早，疾病致残性更高，且男女比例更为均衡。这些发现表明，尽管白种患者获得医疗服务的机会相同，但疾病表型仍因种族而异。
