Gentile S, Marmo R, Costume A, Orlando C, D'Alessandro R, De Bellis G, Porcellini M, Coltorti M
Acta Diabetol Lat. 1986 Apr-Jun;23(2):165-70. doi: 10.1007/BF02624676.
In 9 healthy subjects we evaluated the effect of a constant ranitidine infusion (100 mg) on glucose (mg/dl), insulin (microU/ml) and C-peptide (ng/ml) serum levels promoted by oral glucose tolerance test (75 g). Ranitidine significantly increased the area under concentration/time curves for glucose and insulin but not that of C-peptide. Our data indicate that ranitidine does not affect pancreatic insulin release nor peripheral glucose utilization and are consistent with the hypothesis that ranitidine influences the hepatic clearance of glucose and insulin both of which undergo high first-pass liver extraction.
在9名健康受试者中，我们评估了持续输注雷尼替丁（100毫克）对口服葡萄糖耐量试验（75克）所促进的血糖（毫克/分升）、胰岛素（微单位/毫升）和C肽（纳克/毫升）血清水平的影响。雷尼替丁显著增加了血糖和胰岛素的浓度/时间曲线下面积，但未增加C肽的曲线下面积。我们的数据表明，雷尼替丁不影响胰腺胰岛素释放和外周葡萄糖利用，这与雷尼替丁影响葡萄糖和胰岛素的肝脏清除率的假设一致，葡萄糖和胰岛素在肝脏中均经历高首过提取。
