Pediatric Neurology Unit, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Pediatric Neurology Unit, Università Cattolica del Sacro Cuore Roma, Rome, Italy.
Dev Med Child Neurol. 2022 Jul;64(7):863-870. doi: 10.1111/dmcn.15201. Epub 2022 Mar 17.
To describe the profile of global and single items of the Hammersmith Infant Neurological Examination (HINE) in a population of low-risk infants born very preterm during the first year of life.
The HINE was performed at 3, 6, 9, and 12 months' corrected age in a population of low-risk infants born preterm with a gestational age of fewer than 32 weeks and with normal or minimal changes on neuroimaging.
A total of 174 infants born preterm (96 males, 78 females; mean gestational age = 27 weeks [SD = 1.8], range 23-31 weeks) fulfilled the inclusion criteria. The 10th centile cut-off score with median and range was reported for the HINE global and subsection scores. A progressive increase in global HINE scores was observed. Most of the single items, especially those related to tone, posture, and reflexes, showed progressive maturation.
Our results, which provide longitudinal data for single-item and global scores in a population of low-risk infants born very preterm, can be used as a reference in both clinical and research settings to monitor early neurological signs in these infants. These data could be used as normative data when examining low-risk infants born preterm.
描述在生命第一年极低出生体重早产儿人群中，Hammersmith 婴儿神经学检查（HINE）的整体表现和单项评分。
在神经影像学检查正常或轻微改变的前提下，对胎龄<32 周的极低出生体重早产儿进行 HINE 检查，检查时间分别为矫正月龄 3、6、9 和 12 个月。
共有 174 名早产儿（男 96 名，女 78 名；平均胎龄 27 周 [标准差 1.8]，范围 23-31 周）符合纳入标准。报告了 HINE 整体和各亚项评分的第 10 百分位数截断值、中位数和范围。观察到整体 HINE 评分逐渐增加。大多数单项评分，尤其是与肌张力、姿势和反射相关的单项评分，表现出逐渐成熟。
本研究结果为极低出生体重早产儿提供了单项目和整体评分的纵向数据，可用于临床和研究环境中监测这些婴儿的早期神经体征。在检查极低出生体重早产儿时，这些数据可用作参考标准。
