Naccarelli G V, Dougherty A H, Berns E, Rinkenberger R L
Am J Cardiol. 1986 Aug 29;58(5):31C-36C. doi: 10.1016/0002-9149(86)90101-3.
Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.
关于判断抗心律失常药物对室上性心律失常患者疗效的指南很少。文中提供了有关室上性心律失常发作频率和持续时间的有用定义，并概述了非侵入性心电图和侵入性电生理技术的完全和部分疗效标准。对于室上性心动过速终止和预防的疗效研究，建议采用几种开放标签、双盲、平行和交叉研究设计。这些建议对于设计新的药物试验很有用，这些试验需要正确评估抗心律失常药物治疗各种室上性心律失常的疗效。
