The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel.
Braun School of Public Health, The Hebrew University of Jerusalem, Jerusalem, Israel.
J Crohns Colitis. 2022 Sep 8;16(9):1397-1404. doi: 10.1093/ecco-jcc/jjac043.
Pre- and perinatal events may be associated with an increased risk of inflammatory bowel disease [IBD]. We aimed to investigate the role of pre- and perinatal factors as potential risk factors for the development of IBD in a population with a follow-up of 50 years.
We conducted a nested case-control study, reporting IBD incidence among individuals born in 1964-76, for whom pre- and perinatal exposures were reported as part of the Jerusalem Perinatal Study [JPS], by linking them to the database of the epidemiology group of the Israeli IBD Research Nucleus [epi-IIRN], including all IBD patients in Israel since 2005 and their matched controls.
We identified 2789 individuals within the epi-IIRN cohort who were also included in the JPS cohort [n = 90 079]: 746 IBD patients (405 with Crohn's disease [CD] and 341 with ulcerative colitis [UC]) and 2043 non-IBD controls. Those with a 'Non-western' family origin had decreased odds of developing CD and UC. High socioeconomic status was associated with CD but not UC. Low birth weight [≤2500 g] occurred less frequently in IBD cases compared to controls, especially in UC patients, showing a protective effect. Being the first born was associated with CD, and having older siblings lowered the odds of developing CD, decreasing 7% with each additional sibling. Smoking and breastfeeding data were available for a subset of individuals, but neither was associated with IBD development.
This population-based study identifies several pre- and perinatal variables as predictors of IBD development. This information may be helpful to facilitate implementation of early diagnosis interventions and family follow-up protocols.
围生期和产前事件可能与炎症性肠病（IBD）的风险增加有关。我们旨在研究围生期和产前因素作为潜在危险因素在随访 50 年后对 IBD 发病的作用。
我们进行了一项巢式病例对照研究，报告了出生于 1964-76 年的人群中 IBD 的发病率，这些人作为耶路撒冷围产期研究（JPS）的一部分报告了围生期和产前暴露情况，通过将他们与以色列 IBD 研究核心组的流行病学组数据库（epi-IIRN）联系起来，包括自 2005 年以来以色列所有的 IBD 患者及其匹配对照。
我们在 epi-IIRN 队列中确定了 2789 名个体，他们也被纳入了 JPS 队列[n=90079]：746 名 IBD 患者（405 名克罗恩病[CD]和 341 名溃疡性结肠炎[UC]）和 2043 名非 IBD 对照。非西方家庭出身的人患 CD 和 UC 的几率较低。高社会经济地位与 CD 相关，但与 UC 无关。低出生体重[≤2500g]在 IBD 病例中比对照组少见，尤其是在 UC 患者中，具有保护作用。作为第一个出生的人与 CD 相关，有更多的兄弟姐妹降低了患 CD 的几率，每增加一个兄弟姐妹降低 7%。有一小部分个体有吸烟和母乳喂养的数据，但两者均与 IBD 发病无关。
这项基于人群的研究确定了一些围生期和产前变量作为 IBD 发展的预测因素。这些信息可能有助于促进早期诊断干预和家庭随访方案的实施。
