Wang Guo-Jie, Tian Ye, Zhang Hui-Ying
Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin 300052,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Feb;44(1):158-163. doi: 10.3881/j.issn.1000-503X.14235.
The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and α-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism.
脂肪酸去饱和酶2（FADS2）基因编码δ-6去饱和酶（D6D），是脂肪酸去饱和酶基因家族的成员。D6D是催化亚油酸和α-亚麻酸转化为长链多不饱和脂肪酸（LC-PUFA）的关键酶。LC-PUFA在调节生物体糖脂代谢中起关键作用。近年来，D6D的活性和FADS2基因的单核苷酸多态性（SNP）已成为糖脂代谢研究中的热点话题。本文综述了FADS2基因在糖脂代谢中的作用。
