Department of Psychology, University of Trier, Germany.
Neurosci Biobehav Rev. 2022 May;136:104622. doi: 10.1016/j.neubiorev.2022.104622. Epub 2022 Mar 15.
The parasympathetic nervous system modulates inflammation through efferent vagus nerve signaling. Tracey (2002) termed this process as the cholinergic anti-inflammatory pathway (CAP). Interest in the potential practical use of this immune-modulatory process is increasing alongside increasing appreciation for the role of systemic inflammation in the etiology of somatic and psychological disease. A diverse literature exists providing expansive correlational evidence and some preliminary experimental evidence of the CAP in humans. However, so far this literature has not been well integrated and critically evaluated. This review describes the current state-of-the-art of research into vagus nerve driven parasympathetic control of inflammation in humans. Substantial limitations and gaps in the literature are identified, and promising directions for future research are highlighted.
副交感神经系统通过传出迷走神经信号来调节炎症。特蕾西（2002 年）将这一过程称为胆碱能抗炎途径（CAP）。随着人们对全身炎症在躯体和心理疾病病因学中作用的认识不断提高，对这一免疫调节过程潜在实际应用的兴趣也在不断增加。目前已经有大量文献提供了广泛的相关性证据，以及一些关于人类 CAP 的初步实验证据。然而，到目前为止，这些文献还没有得到很好的整合和批判性评价。这篇综述描述了目前关于人类迷走神经驱动的副交感神经对炎症控制的研究现状。文献中存在着实质性的局限性和空白，同时也强调了未来研究的有前景的方向。
