Gao Yuan, Xu Yan, Dong Zhijia, Guo Yuyang, Luo Jianghan, Wang Fuling, Yan Lijun, Zou Xiang
School of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China.
Molecules. 2025 Feb 24;30(5):1028. doi: 10.3390/molecules30051028.
This paper reviewed the diversity of endophytic fungi and their interactions with medicinal plants, along with the research methodologies utilized to investigate these interactions. It mainly includes the diversity of endophytic fungi, as well as distribution diversity, species diversity, and the diversity of their metabolites and functions, including antibacterial, anti-inflammatory, anti-tumor, insecticidal, antioxidant capabilities, and so on. The research methodologies employed to investigate the interactions between endophytic fungi and medicinal plants are categorized into metagenomics, transcriptomics, metatranscriptomics, proteomics, and metabolomics. Furthermore, this study anticipates the potential applications of secondary metabolites derived from endophytic fungi in both medicine and agriculture.
本文综述了内生真菌的多样性及其与药用植物的相互作用，以及用于研究这些相互作用的研究方法。它主要包括内生真菌的多样性，以及分布多样性、物种多样性及其代谢产物和功能的多样性，包括抗菌、抗炎、抗肿瘤、杀虫、抗氧化能力等。用于研究内生真菌与药用植物之间相互作用的研究方法分为宏基因组学、转录组学、宏转录组学、蛋白质组学和代谢组学。此外，本研究还展望了内生真菌次生代谢产物在医药和农业方面的潜在应用。
