Merino Marisa M, Seum Carole, Dubois Marine, Gonzalez-Gaitan Marcos
Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Nat Cell Biol. 2022 Apr;24(4):424-433. doi: 10.1038/s41556-022-00858-3. Epub 2022 Mar 17.
During development, morphogen gradients encode positional information to pattern morphological structures during organogenesis. Some gradients, like that of Dpp in the fly wing, remain proportional to the size of growing organs-that is, they scale. Gradient scaling keeps morphological patterns proportioned in organs of different sizes. Here we show a mechanism of scaling that ensures that, when the gradient is smaller than the organ, cell death trims the developing tissue to match the size of the gradient. Scaling is controlled by molecular associations between Dally and Pentagone, known factors involved in scaling, and a key factor that mediates cell death, Flower. We show that Flower activity in gradient expansion is not dominated by cell death, but by the activity of Dally/Pentagone on scaling. Here we show a potential connection between scaling and cell death that may uncover a molecular toolbox hijacked by tumours.
在发育过程中，形态发生素梯度编码位置信息，以在器官发生期间构建形态结构。一些梯度，如果蝇翅膀中的Dpp梯度，与生长中器官的大小保持比例关系——也就是说，它们会缩放。梯度缩放使不同大小器官中的形态模式保持比例协调。在这里，我们展示了一种缩放机制，该机制确保当梯度小于器官时，细胞死亡会修剪发育中的组织以匹配梯度的大小。缩放由Dally和Pentagone（已知的参与缩放的因子）与介导细胞死亡的关键因子Flower之间的分子关联控制。我们表明，Flower在梯度扩展中的活性并非由细胞死亡主导，而是由Dally/Pentagone对缩放的活性主导。在这里，我们展示了缩放与细胞死亡之间的潜在联系，这可能揭示出肿瘤劫持的一个分子工具箱。
