Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, Zhejiang, China.
Department of Computer Science, University of Tsukuba, Tsukuba, Ibaraki, 305-8577, Japan.
Curr Top Med Chem. 2022;22(23):1897-1906. doi: 10.2174/1568026622666220317164016.
High costs and risks are common issues in traditional drug research and development. Usually, it takes a long time to research and develop a drug, the effects of which are limited to relatively few targets. At present, studies are aiming to identify unknown new uses for existing drugs. Drug repositioning enables drugs to be quickly launched into clinical practice at a low cost because they have undergone clinical safety testing during the development process, which can greatly reduce costs and the risks of failed development. In addition to existing drugs with known indications, drugs that were shelved because of clinical trial failure can also be options for repositioning. In fact, many widely used drugs are identified via drug repositioning at present. This article reviews some popular research areas in the field of drug repositioning and briefly introduces the advantages and disadvantages of these methods, aiming to provide useful insights into future development in this field.
高成本和高风险是传统药物研发中常见的问题。通常，研发一种药物需要很长时间，而且其效果仅限于相对较少的靶点。目前，研究旨在确定现有药物的未知新用途。药物重定位可使药物以低成本快速投入临床实践，因为它们在开发过程中已经经过了临床安全性测试，这可以大大降低成本和开发失败的风险。除了具有已知适应症的现有药物外，因临床试验失败而被搁置的药物也可以作为重定位的选择。事实上，目前许多广泛使用的药物都是通过药物重定位确定的。本文综述了药物重定位领域的一些热门研究领域，并简要介绍了这些方法的优缺点，旨在为该领域的未来发展提供有用的见解。
