Lildholdt T, Felding J U, Juul A, Kristensen S, Schouenborg P
Arch Otorhinolaryngol. 1986;243(3):167-9. doi: 10.1007/BF00470613.
A prospective open and controlled study of perioperative antibiotics was conducted in patients with chronic otitis media (COM). Drug efficacy was found in a subgroup of 26 patients, who were characterized by preoperative aural drainage culturing Pseudomonas aeruginosa. Fourteen of these patients were randomized to receive ceftazidime (cephalosporin) for 5 days at the operation, while 12 had no antibiotic treatment. The occurrence of subsequent aural drainage was compared with the actual clinical and microbiological conditions of the ears 2 months after the operation; statistically significant differences were found in favor of the group treated with ceftazidime. Further studies must define the role of ceftazidime and other antibiotics in the management of patients with COM.
对慢性中耳炎（COM）患者进行了一项关于围手术期抗生素的前瞻性开放对照研究。在一个由26名患者组成的亚组中发现了药物疗效，这些患者的特征是术前耳引流培养出铜绿假单胞菌。其中14名患者被随机分配在手术时接受头孢他啶（头孢菌素）治疗5天，而12名患者未接受抗生素治疗。将随后耳引流的发生情况与术后2个月耳朵的实际临床和微生物状况进行了比较；发现使用头孢他啶治疗的组有统计学上的显著差异。进一步的研究必须确定头孢他啶和其他抗生素在COM患者管理中的作用。
