Cho Hye Eun, Yang Seung Bum, Gi Mi Young, Cha Ju Ae, Park So Young, Yoon Hyun
Department of Dental Hygiene, Kwangju Womens's University, Gwangsan-gu, South Korea.
Department of Medical Non-commissioned Officer, Wonkwang Health Science University, Iksan-si, South Korea.
Endocr Res. 2022 Feb-May;47(2):80-88. doi: 10.1080/07435800.2022.2053540. Epub 2022 Mar 18.
This study was conducted to assess the relationship between the lipid accumulation product index (LAP) and the homeostasis model assessment for insulin resistance (HOMA-IR) and beta-cell function (HOMA-) in Korean adults with or without type 2 diabetes mellitus (T2DM).
The study was carried out using data from the 2015 Korean National Health and Nutrition Examination Survey (KNHANES) and included 4,922 adults aged 20 or older.
There were several key findings. First, in overall population, after adjusting for related variables, HOMA-IR ( < .001) and HOMA- ( < .001) level were positively associated with quartiles of LAP. Second, in non-T2DM group, HOMA-IR ( < .001) and HOMA- level ( < .001) were positively associated with quartiles of LAP. Third, in T2DM group, HOMA-IR ( < .001) level was positively associated with the quartiles of LAP, but HOMA- ( = .153) level was not significant. In addition, HOMA- level was increased with an increasing metabolic syndrome component in non-T2DM ( < .001) but not in T2DM ( = .267).
LAP was positively associated with both HOMA-IR and HOMA- in non-diabetic Korean adults. However, LAP was positively associated with HOMA-IR in Korean adults with T2DM, while the association with HOMA- was not significant.
本研究旨在评估韩国2型糖尿病（T2DM）患者及非T2DM患者中脂质蓄积产物指数（LAP）与胰岛素抵抗稳态模型评估（HOMA-IR）及β细胞功能（HOMA-β）之间的关系。
本研究采用2015年韩国国民健康与营养检查调查（KNHANES）的数据，纳入了4922名20岁及以上的成年人。
有几个关键发现。首先，在总体人群中，校正相关变量后，HOMA-IR（P<0.001）和HOMA-β（P<0.001）水平与LAP四分位数呈正相关。其次，在非T2DM组中，HOMA-IR（P<0.001）和HOMA-β水平（P<0.001）与LAP四分位数呈正相关。第三，在T2DM组中，HOMA-IR（P<0.001）水平与LAP四分位数呈正相关，但HOMA-β（P=0.153）水平无显著相关性。此外，非T2DM组中HOMA-β水平随代谢综合征组分数量增加而升高（P<0.001），而T2DM组中则无此现象（P=0.267）。
在非糖尿病韩国成年人中，LAP与HOMA-IR和HOMA-β均呈正相关。然而，在患有T2DM的韩国成年人中，LAP与HOMA-IR呈正相关，而与HOMA-β的相关性不显著。
